PMID- 22906519
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20220317
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 74
IP  - 4
DP  - 2013 Aug 15
TI  - Altered brain-derived neurotrophic factor expression in the ventral tegmental 
      area, but not in the hippocampus, is essential for antidepressant-like effects of 
      electroconvulsive therapy.
PG  - 305-12
LID - S0006-3223(12)00651-8 [pii]
LID - 10.1016/j.biopsych.2012.07.025 [doi]
AB  - BACKGROUND: Impaired neuronal plasticity and, specifically, altered expression of 
      brain-derived neurotrophic factor (BDNF) were shown to play a critical role in 
      depressive behavior and the mechanism of various antidepressant treatments 
      including electroconvulsive therapy (ECT). Interestingly, opposing roles were 
      suggested for BDNF in the hippocampus and the ventral tegmental area (VTA), while 
      interactions between these regions were shown on various levels. Here, we 
      evaluated whether BDNF plays an essential role in the antidepressant-like effects 
      of ECT and performed a direct comparison between BDNF manipulations in the VTA 
      and the hippocampus. METHODS: Knockdown or overexpression of BDNF was induced in 
      hippocampus or VTA of rats by microinjection of specific lentiviral vectors. The 
      effects of these manipulations on antidepressant outcomes of ECT were evaluated 
      by the forced swim test and by sucrose preference measurements, and BDNF 
      expression levels were assessed in other reward-related brain regions. RESULTS: 
      Here, we show that whereas ECT increased hippocampal BDNF expression, induction 
      of hippocampal BDNF knockdown did not block its antidepressant-like effect. 
      Importantly, we found that ECT caused a robust reduction in VTA BDNF levels. 
      Moreover, VTA BDNF knockdown alone was sufficient to induce an 
      antidepressant-like effect, and VTA BDNF overexpression blocked the 
      antidepressant-like effect of ECT. CONCLUSIONS: While neuroplastic alterations, 
      as expressed by changes in BDNF expression within different brain regions, are 
      induced by ECT, the antidepressant-like effect of ECT in an animal model depends 
      on reduction of VTA BDNF expression but not on the elevation of hippocampal BDNF 
      expression.
CI  - Copyright (c) 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Taliaz, Dekel
AU  - Taliaz D
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel; 
      Department of Life Science, Ben Gurion University, Beer Sheva, Israel.
FAU - Nagaraj, Vini
AU  - Nagaraj V
FAU - Haramati, Sharon
AU  - Haramati S
FAU - Chen, Alon
AU  - Chen A
FAU - Zangen, Abraham
AU  - Zangen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120817
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Electroconvulsive Therapy
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ventral Tegmental Area/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - ECT
OT  - VTA
OT  - depression
OT  - hippocampus
OT  - rat model
EDAT- 2012/08/22 06:00
MHDA- 2014/01/31 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/04/23 00:00 [received]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - S0006-3223(12)00651-8 [pii]
AID - 10.1016/j.biopsych.2012.07.025 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2013 Aug 15;74(4):305-12. doi: 10.1016/j.biopsych.2012.07.025. 
      Epub 2012 Aug 17.