PMID- 2290693
OWN - NLM
STAT- MEDLINE
DCOM- 19910403
LR  - 20181130
IS  - 0369-8114 (Print)
IS  - 0369-8114 (Linking)
VI  - 38
IP  - 10
DP  - 1990 Dec
TI  - [Stimulation of epidermal growth in equivalent skin by tissue inhibitor of 
      metalloproteases].
PG  - 1029-33
AB  - Tissue inhibitor of metalloproteases (TIMP) is a major regulator of extracellular 
      matrix synthesis and degradation. Moreover elevated tissue inhibitor of 
      metalloproteases levels are found in the blister fluid of many diseases, 
      suggesting that tissue inhibitor of metalloproteases plays a role in epidermal 
      and dermal wound healing. The aim of this work was to study the effects of human 
      recombinant tissue inhibitor of metalloproteases in a skin equivalent model used 
      to evaluate the effects of drugs on epidermal and dermal components. Planimetry, 
      DNA assays, and histologic studies showed that tissue inhibitor of 
      metalloproteases enhanced the growth of normal human keratinocytes on dermal 
      equivalent. Thus, the extracellular matrix regulator tissue inhibitor of 
      metalloproteases also stimulates the growth of keratinocytes. Identity of the 
      gene encoding tissue inhibitor of metalloproteases and Erythroid Potentiating 
      Activity (EPA) has been reported. The effects of tissue inhibitor of 
      metalloproteases on keratinocytes described herein are reminiscent of the 
      stimulating effect of erythroid potentiating activity on the growth of erythroid 
      precursors.
FAU - Bertaux, B
AU  - Bertaux B
AD  - Laboratoire de Recherche Dermatologique, INSERM U 312, Creteil, France.
FAU - Hornebeck, W
AU  - Hornebeck W
FAU - Courtalon, A
AU  - Courtalon A
FAU - Lebreton, C
AU  - Lebreton C
FAU - Dubertret, L
AU  - Dubertret L
LA  - fre
PT  - Journal Article
TT  - Stimulation de la croissance epidermique dans la peau equivalente par 
      l'inhibiteur tissulaire des metalloproteinases.
PL  - France
TA  - Pathol Biol (Paris)
JT  - Pathologie-biologie
JID - 0265365
RN  - 0 (Protease Inhibitors)
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - DNA/analysis
MH  - Epidermal Cells
MH  - Epidermis/drug effects/*growth & development
MH  - Humans
MH  - Metalloendopeptidases/*antagonists & inhibitors
MH  - Protease Inhibitors/*pharmacology
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
PST - ppublish
SO  - Pathol Biol (Paris). 1990 Dec;38(10):1029-33.