PMID- 22908886
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20211021
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Print)
IS  - 0954-0121 (Linking)
VI  - 25
IP  - 4
DP  - 2013
TI  - The impact of specific HIV treatment-related adverse events on adherence to 
      antiretroviral therapy: a systematic review and meta-analysis.
PG  - 400-14
LID - 10.1080/09540121.2012.712667 [doi]
AB  - Poor adherence to antiretroviral therapies (ARTs) in human immunodeficiency virus 
      (HIV)-infected patients increases the risk of incomplete viral suppression, 
      development of viral resistance, progression to acquired immune deficiency 
      syndrome and death. This study assesses the impact of specific treatment-related 
      adverse events (AEs) on adherence to ART in the adult HIV patient population. A 
      systematic review of studies involving adult HIV-infected patients aged >/= 16 
      years that reported an odds ratio (OR) for factors affecting adherence to ART was 
      conducted through a search of the EMBASE((R)) and Medline((R)) databases. Database 
      searches were complemented with a search of titles in the bibliographies of 
      review papers. Studies conducted in populations limited to a particular 
      demographic characteristic or behavioural risk were excluded. To qualify for 
      inclusion into a meta-analysis, treatment-related AEs had to be defined similarly 
      across studies. Also, multiple ORs from the same study were included where study 
      sub-groups were distinct. Random effects models were used to pool ORs. In total, 
      19 studies and 18 ART-related AEs were included in meta-analyses. Adherence to 
      ART was significantly lower in patients with non-specific AEs than in patients 
      who did not experience AEs [OR = 0.623; 95% confidence interval (CI): 
      0.465-0.834]. Patients with specific AEs such as fatigue (OR = 0.631; 95% CI: 
      0.433-0.918), confusion (OR = 0.349; 95% CI: 0.184-0.661), taste disturbances (OR 
      = 0.485; 95% CI: 0.303-0.775) and nausea (OR = 0.574; 95% CI: 0.427-0.772) were 
      significantly less likely to adhere to ART compared to patients without these 
      AEs. Knowledge of specific treatment-related AEs may allow for targeted 
      management of these events and a careful consideration of well-tolerated 
      treatment regimens to improve ART adherence and clinical outcomes.
FAU - Al-Dakkak, Imad
AU  - Al-Dakkak I
AD  - HERON Evidence Development Ltd, Butterfield Business and Technology Park, 
      Stopsley, Luton, UK.
FAU - Patel, Seema
AU  - Patel S
FAU - McCann, Eilish
AU  - McCann E
FAU - Gadkari, Abhijit
AU  - Gadkari A
FAU - Prajapati, Girish
AU  - Prajapati G
FAU - Maiese, Eric M
AU  - Maiese EM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120822
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-HIV Agents/*administration & dosage/*adverse effects
MH  - CD4 Lymphocyte Count
MH  - Confusion/chemically induced
MH  - Disease Progression
MH  - Drug Administration Schedule
MH  - Drug Resistance, Viral
MH  - Fatigue/chemically induced
MH  - Female
MH  - HIV Infections/complications/*drug therapy/immunology
MH  - Humans
MH  - Male
MH  - *Medication Adherence/psychology/statistics & numerical data
MH  - Nausea/chemically induced
MH  - Patient Education as Topic
MH  - Taste Disorders/chemically induced
PMC - PMC3613968
EDAT- 2012/08/23 06:00
MHDA- 2013/09/27 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
AID - 10.1080/09540121.2012.712667 [doi]
PST - ppublish
SO  - AIDS Care. 2013;25(4):400-14. doi: 10.1080/09540121.2012.712667. Epub 2012 Aug 
      22.