PMID- 22911909
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20200930
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 159B
IP  - 7
DP  - 2012 Oct
TI  - Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive 
      function in obsessive-compulsive disorder.
PG  - 850-8
LID - 10.1002/ajmg.b.32092 [doi]
AB  - In the present study, we have tested the hypothesis that brain-derived 
      neurotrophic factor (BDNF) gene Val66Met polymorphism is associated with 
      obsessive-compulsive disorder (OCD) and also investigated the association between 
      the BDNF Val66Met polymorphism and the performance on tests measuring executive 
      functions in a sample of patients with OCD. A total of 100 patients diagnosed 
      with OCD according to DSM-IV criteria and 110 control subjects were included in 
      this study. Single nucleotide polymorphism (G/A) leading to Val to Met 
      substitution at codon 66 in BDNF was screened in the DNA samples of all 
      participants. The genotype frequencies of BDNF Val66Met polymorphism were 
      compared in OCD patients and healthy controls. The four subgroups of OCD and 
      healthy control subjects, determined according to being Val homozygous or 
      carrying a Met allele, were also compared according to their performance in a 
      battery of neuropsychological tests of executive functions and verbal memory. 
      There was no significant difference for the allele and genotype distributions of 
      BDNF Val66Met polymorphism between the OCD and healthy control groups. Compared 
      to the other three subgroups, OCD-Met carriers were slower on Trail-Making Test 
      part A (TMT A), part B (TMT B) score and its speed-corrected score (TMT B-A). 
      OCD-Met carriers had also poor performance on verbal fluency tasks and several 
      CVLT measures compared only to the healthy control-Met carriers. These results 
      demonstrate that the BDNF Val66Met polymorphism does not appear to be a risk 
      factor for OCD. However, the presence of a BDNF Met allele, which is a known 
      attenuator of BDNF activity, may be associated with a poorer executive 
      functioning in OCD.
CI  - 2012 Wiley Periodicals, Inc.
FAU - Tukel, Rasit
AU  - Tukel R
AD  - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, 
      Istanbul, Turkey. rtukel@gmail.com
FAU - Gurvit, Hakan
AU  - Gurvit H
FAU - Ozata, Berna
AU  - Ozata B
FAU - Ozturk, Nalan
AU  - Ozturk N
FAU - Ertekin, Banu A
AU  - Ertekin BA
FAU - Ertekin, Erhan
AU  - Ertekin E
FAU - Baran, Bengi
AU  - Baran B
FAU - Kalem, Sukriye A
AU  - Kalem SA
FAU - Buyukgok, Deniz
AU  - Buyukgok D
FAU - Direskeneli, Guher S
AU  - Direskeneli GS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120822
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Cognition
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Obsessive-Compulsive Disorder/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Valine/*genetics
EDAT- 2012/08/23 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/07/17 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - 10.1002/ajmg.b.32092 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):850-8. doi: 
      10.1002/ajmg.b.32092. Epub 2012 Aug 22.