PMID- 22912640
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Targeting PKCtheta in alloreactivity and graft-versus-host-disease: unanswered 
      questions and therapeutic potential.
PG  - 259
LID - 10.3389/fimmu.2012.00259 [doi]
LID - 259
AB  - Protein kinase C isoform theta (PKCtheta) is a key modulator of TCR signaling and 
      mediates activation of NF-kappaB, NF-AT, and AP-1 transcription factors. Although in 
      vitro studies of PKCtheta(-/-) T cells have shown impaired activation responses, in 
      vivo studies indicate that PKCtheta requirement is not universal. While PKCtheta is 
      important in induction of experimentally induced autoimmune diseases in mice and 
      generation of Th2 responses, it is not essential for induction of T cell 
      proliferative and cytotoxic responses against influenza virus, LCMV, and vaccinia 
      virus. The context-specific involvement of PKCtheta in T cell responses suggests that 
      inhibition of PKCtheta may be beneficial in some but not all situations. In the bone 
      marrow transplantation (BMT) setting, we have shown that 
      graft-versus-host-disease (GVHD) cannot be induced in the absence of PKCtheta. 
      However, graft-versus-leukemia effects and T cell ability to clear virus 
      infection remains intact. Therefore, PKCtheta is a potential therapeutic target in 
      BMT, inhibition of which may prevent GVHD while retaining anti-tumor and 
      anti-infection responses.
FAU - Bronk, Crystina C
AU  - Bronk CC
AD  - Department of Immunology, Moffitt Cancer Center Tampa, FL, USA.
FAU - Yu, Xue-Zhong
AU  - Yu XZ
FAU - Beg, Amer A
AU  - Beg AA
LA  - eng
GR  - R01 AI082685/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20120814
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3418525
OTO - NOTNLM
OT  - T cell activation
OT  - alloreactivity
OT  - anti-tumor effect
OT  - graft-versus-host-disease
OT  - protein kinase C
EDAT- 2012/08/23 06:00
MHDA- 2012/08/23 06:01
PMCR- 2012/01/01
CRDT- 2012/08/23 06:00
PHST- 2012/04/13 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/08/23 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00259 [doi]
PST - epublish
SO  - Front Immunol. 2012 Aug 14;3:259. doi: 10.3389/fimmu.2012.00259. eCollection 
      2012.