PMID- 22912723
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 8
DP  - 2012
TI  - Reduced connectivity in the self-processing network of schizophrenia patients 
      with poor insight.
PG  - e42707
LID - 10.1371/journal.pone.0042707 [doi]
LID - e42707
AB  - Lack of insight (unawareness of illness) is a common and clinically relevant 
      feature of schizophrenia. Reduced levels of self-referential processing have been 
      proposed as a mechanism underlying poor insight. The default mode network (DMN) 
      has been implicated as a key node in the circuit for self-referential processing. 
      We hypothesized that during resting state the DMN network would show decreased 
      connectivity in schizophrenia patients with poor insight compared to patients 
      with good insight. Patients with schizophrenia were recruited from mental health 
      care centers in the north of the Netherlands and categorized in groups having 
      good insight (n= 25) or poor insight (n = 19). All subjects underwent a resting 
      state fMRI scan. A healthy control group (n = 30) was used as a reference. 
      Functional connectivity of the anterior and posterior part of the DMN, identified 
      using Independent Component Analysis, was compared between groups. Patients with 
      poor insight showed lower connectivity of the ACC within the anterior DMN 
      component and precuneus within the posterior DMN component compared to patients 
      with good insight. Connectivity between the anterior and posterior part of the 
      DMN was lower in patients than controls, and qualitatively different between the 
      good and poor insight patient groups. As predicted, subjects with poor insight in 
      psychosis showed decreased connectivity in DMN regions implicated in 
      self-referential processing, although this concerned only part of the network. 
      This finding is compatible with theories implying a role of reduced 
      self-referential processing as a mechanism contributing to poor insight.
FAU - Liemburg, Edith J
AU  - Liemburg EJ
AD  - Department of Neuroscience, University Medical Center Groningen and BCN 
      NeuroImaging Center, University of Groningen, Groningen, The Netherlands. 
      E.J.Liemburg@umcg.nl
FAU - van der Meer, Lisette
AU  - van der Meer L
FAU - Swart, Marte
AU  - Swart M
FAU - Curcic-Blake, Branislava
AU  - Curcic-Blake B
FAU - Bruggeman, Richard
AU  - Bruggeman R
FAU - Knegtering, Henderikus
AU  - Knegtering H
FAU - Aleman, Andre
AU  - Aleman A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - *Awareness
MH  - Brain/cytology/pathology/physiology/physiopathology
MH  - Case-Control Studies
MH  - Humans
MH  - Male
MH  - Nerve Net/cytology/*pathology/physiology/physiopathology
MH  - Schizophrenia/*pathology/physiopathology
PMC - PMC3415395
COIS- Competing Interests: E.J. Liemburg, MSc reports no financial relationships with 
      commercial interests. Dr. L. van der Meer reports no financial relationships with 
      commercial interests. M. Swart, MSc reports no financial relationships with 
      commercial interests. Dr. B. Curcic-Blake reports no financial relationships with 
      commercial interests. Dr. R. Bruggeman reports no financial relationships with 
      commercial interests. Dr. H. Knegtering is on the speakers list of Janssen-Cilag, 
      BMS and Eli Lilly, and received unrestricted research grants from Eli Lilly, 
      Astra Zeneca, Janssen-Cilag and BMS. These companies had no further role in the 
      selection of literature and interpretation of data; in the writing of the review; 
      and in the decision to submit the manuscript for publication. Dr. A. Aleman 
      reports no financial relationships with commercial interests. Lentis Center for 
      Mental Health Care is not a commercial organization, but a local public health 
      care center without profit-making activities. Being an employee of Lentis does 
      not alter those authors' adherence to all the PLoS ONE policies on sharing data 
      and materials. The authors declare their adherence to all the PLoS ONE policies 
      on sharing data and materials.
EDAT- 2012/08/23 06:00
MHDA- 2013/04/24 06:00
PMCR- 2012/08/09
CRDT- 2012/08/23 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
PHST- 2012/08/09 00:00 [pmc-release]
AID - PONE-D-12-06361 [pii]
AID - 10.1371/journal.pone.0042707 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(8):e42707. doi: 10.1371/journal.pone.0042707. Epub 2012 Aug 9.