PMID- 22913207
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20181201
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Jun
TI  - Metabolic responses in non-small cell lung cancer after hypofractionated 
      stereotactic radiotherapy PET and hypofractionated radiotherapy.
PG  - 755-62
AB  - BACKGROUND: The aim of our study was to evaluate the pattern of local failure 
      after stereotactic body radiotherapy (SBRT) of non small cell lung cancer (NSCLC) 
      lesions relating to different type of 18F-FDG positron emission tomography (PET) 
      response. METHODS: Thirteen NSCLC patients for a total of 15 lesions (primary 
      early or locally advanced and metastases) underwent PET before and 6 months after 
      SBRT. Maximum standard uptake value (SUVmax) <2.5 was considered as cut off for 
      complete response (CR) while lesion reduction > or =50% with residual value above 
      2.5 for partial response (PR). RESULTS: With a median follow up of 30 months pre- 
      and post-SBRT mean SUV max values were 8.2 (range 14.2-3.7) and 2.4 (range 
      12.9-0), respectively. No "in field recurrence" was observed while 3 cases of 
      "out field recurrence" occurred as regional nodes progression at 7.8 and 14 
      months after treatment. Three years overall survival, local control and distant 
      metastases free survival were respectively 66.7%, 63.3% and 44.4%. Actuarial 75% 
      and 53.3% 3-year local control, 60% and 40% 3-years distant metastases free 
      survival were observed for complete and partial PET response, respectively, after 
      SBRT. Thereafter, 60% and 50% 3-year overall survival were observed for complete 
      and partial response. CONCLUSIONS: Clinical results were significantly better for 
      "responder" than "non responder" and for "complete" than "partial response" 
      group. Moreover, our data seem to confirm that a significant subset of patients 
      maintain a low metabolic activity without developing local relapse on longer 
      follow up.
FAU - Ursino, S
AU  - Ursino S
AD  - Radiotherapy Department, School of Medicine, University Hospital S. Anna, 
      Ferrara, Italy. s.ursino@hotmail.it
FAU - Fiorica, F
AU  - Fiorica F
FAU - Colosimo, C
AU  - Colosimo C
FAU - Micucci, M
AU  - Micucci M
FAU - Stefanelli, A
AU  - Stefanelli A
FAU - Berretta, M
AU  - Berretta M
FAU - Panareo, S
AU  - Panareo S
FAU - De Biasi, V
AU  - De Biasi V
FAU - Feggi, L M
AU  - Feggi LM
FAU - Zini, G
AU  - Zini G
FAU - Cartei, F
AU  - Cartei F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/metabolism/mortality/*therapy
MH  - *Dose Fractionation, Radiation
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnostic imaging/metabolism/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography/*methods
MH  - *Radiosurgery
EDAT- 2012/08/24 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2012 Jun;16(6):755-62.