PMID- 22914258
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20140430
IS  - 1477-0393 (Electronic)
IS  - 0748-2337 (Linking)
VI  - 30
IP  - 4
DP  - 2014 May
TI  - Effect of Pleurotus florida lectin (PFL) on arsenic-induced activities of 
      splenocytes in rat.
PG  - 336-46
LID - 10.1177/0748233712456064 [doi]
AB  - The present study was undertaken to investigate the protective effect of 
      Pleurotus florida lectin (PFL) against arsenic-induced cytotoxicity and oxidative 
      damages in freshly isolated splenocytes of rodents. Our finding indicated that 
      arsenic caused reduction in cell adhesion, morphological alterations, cell 
      proliferation, nitro blue tetrazolium (NBT) index, superoxide dismutase (SOD) 
      activity, catalase (CAT) activity and relative mRNA expression of SOD2 in 
      relation to housekeeping gene glyceraldehyde 3-phosphate dehydrogenase (GAPDH) 
      and increased production of nitric oxide (NO), protein carbonyl (PC) and lipid 
      peroxidation levels (LPO) assembled to play key factors for cytotoxicity and 
      oxidative stress. PFL normalized cellular damages and enhanced SOD production 
      pathway relating to gene expression. Further studies are needed to address 
      effective phytochemicals of the edible mushroom and their mechanism.
FAU - Rana, Tanmoy
AU  - Rana T
AD  - 1Indian Veterinary Research Institute, Eastern Regional Station, Kolkata, India.
FAU - Bera, Asit Kumar
AU  - Bera AK
FAU - Bhattacharya, Debasis
AU  - Bhattacharya D
FAU - Das, Subhashree
AU  - Das S
FAU - Pan, Diganta
AU  - Pan D
FAU - Das, Subrata Kumar
AU  - Das SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120822
PL  - England
TA  - Toxicol Ind Health
JT  - Toxicology and industrial health
JID - 8602702
RN  - 0 (Biological Products)
RN  - 0 (Fungal Proteins)
RN  - 0 (Lectins)
RN  - 0 (Protective Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.- (Oxidoreductases)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Arsenic/toxicity
MH  - Biological Products/*pharmacology
MH  - Cell Adhesion/drug effects
MH  - Cell Shape/drug effects
MH  - Cells, Cultured
MH  - DNA Fragmentation/drug effects
MH  - Fungal Proteins/*pharmacology
MH  - Lectins/*pharmacology
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Nitric Oxide/analysis/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Oxidoreductases/analysis/metabolism
MH  - Pleurotus/*chemistry
MH  - Protective Agents/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Spleen/cytology
OTO - NOTNLM
OT  - Arsenic
OT  - mushroom lectin
OT  - oxidative stress
OT  - rat
OT  - splenoctyes
EDAT- 2012/08/24 06:00
MHDA- 2015/02/13 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - 0748233712456064 [pii]
AID - 10.1177/0748233712456064 [doi]
PST - ppublish
SO  - Toxicol Ind Health. 2014 May;30(4):336-46. doi: 10.1177/0748233712456064. Epub 
      2012 Aug 22.