PMID- 22914434
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20221207
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 13
IP  - 7
DP  - 2012 Oct
TI  - HLA and SNP haplotype mapping in the Japanese population.
PG  - 543-8
LID - 10.1038/gene.2012.35 [doi]
AB  - The genes that encode the human leukocyte antigen (HLA) class I and II molecules 
      are highly polymorphic and located in the major histocompatibility complex (MHC) 
      region, where there is a high density of immune-related genes. Numerous studies 
      have identified disease susceptibility in this region; however, interpretation of 
      the results is complicated because of the strong linkage disequilibrium (LD) 
      among HLA alleles and single-nucleotide polymorphisms (SNPs). In this study, we 
      evaluated the correlation between the HLA alleles of 6 loci (HLA-A, C, B, DRB1, 
      DQB1 and DPB1) and 6502 SNPs within 8 Mb of the extended MHC region using 92 
      Japanese subjects to identify SNP single loci or haplotypes that tag HLA alleles. 
      We found a total of 39 HLA alleles that showed strong LD (r(2)>/=0.8) with SNPs, 
      including 11 non-synonymous SNPs in non-HLA genes. In addition, we identified 
      several SNP haplotypes in strong LD (r(2)>/=0.8) with eight HLA alleles, which do 
      not possess tag SNPs. Our detailed list of tag SNPs and haplotypes could be 
      utilized for a better understanding of the results obtained by association 
      studies in the Japanese population and for the characterization of the 
      differences in LD structures between races.
FAU - Kitajima, H
AU  - Kitajima H
AD  - Division of Genome Analysis, Research Center for Genetic Information, Medical 
      Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
FAU - Sonoda, M
AU  - Sonoda M
FAU - Yamamoto, K
AU  - Yamamoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120823
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Asian People/*genetics
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Japan
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/08/24 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - gene201235 [pii]
AID - 10.1038/gene.2012.35 [doi]
PST - ppublish
SO  - Genes Immun. 2012 Oct;13(7):543-8. doi: 10.1038/gene.2012.35. Epub 2012 Aug 23.