PMID- 22917219
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20220311
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 10
DP  - 2012 Aug 21
TI  - Change in health status (EQ-5D) over 5 years among individuals with and without 
      type 2 diabetes mellitus in the SHIELD longitudinal study.
PG  - 99
LID - 10.1186/1477-7525-10-99 [doi]
AB  - BACKGROUND: Health-related quality of life studies among adults with type 2 
      diabetes mellitus, using the EQ-5D, have been short term and have not assessed 
      change over years. This study assessed the change in health status and 
      health-related quality of life over 5 years among individuals with and without 
      diabetes. METHODS: Respondents to the US Study to Help Improve Early evaluation 
      and management of risk factors Leading to Diabetes (SHIELD) completed the 
      EuroQol-5D (EQ-5D) at baseline (2004) and 5 years later (2009). Visual analog 
      scale (VAS) score and health index score were computed at baseline and year 5, 
      and the change over 5 years was measured for individuals with type 2 diabetes 
      mellitus (T2DM) and those without diabetes, and T2DM adults with and without 
      diabetic complications. Linear regression models were used to determine change in 
      EQ-5D score, controlling for age, gender, race, education, household income, and 
      body mass index (BMI). RESULTS: There was significantly greater decline in the 
      EQ-5D index score in the T2DM group (-0.031 [SD 0.158]), compared with those 
      without diabetes (-0.016 [0.141], p = 0.001). Compared with respondents without 
      diabetes, those with T2DM had a larger reduction in EQ-5D index score, after 
      controlling for demographics (p = 0.001). EQ-5D VAS score declined over 5 years 
      for both groups: -1.42 (18.1) for the T2DM group, and -0.63 (15.8) for the group 
      without diabetes, but the between-group difference was not significant either 
      before (p = 0.09) or after (p = 0.12), controlling for demographics. T2DM 
      respondents with diabetic complications had a greater decline in EQ-5D scores 
      than T2DM respondents without complications (p < 0.05). CONCLUSION: Over a 5-year 
      period, health status of respondents with T2DM declined significantly compared 
      with those with no diabetes, indicating that the burden of the disease has a 
      long-term detrimental impact. This decline in health status is likely to impact 
      utility scores (fewer quality-adjusted life years) for economic evaluations.
FAU - Grandy, Susan
AU  - Grandy S
AD  - AstraZeneca LP, Wilmington, DE, USA.
FAU - Fox, Kathleen M
AU  - Fox KM
CN  - SHIELD Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120821
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/complications/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Diabetic Nephropathies/diagnosis
MH  - Diabetic Retinopathy/diagnosis
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Health Status Indicators
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement/statistics & numerical data
MH  - *Quality of Life
MH  - Quality-Adjusted Life Years
MH  - Regression Analysis
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - *Surveys and Questionnaires
MH  - United States/epidemiology
PMC - PMC3490883
FIR - Bays, Harold
IR  - Bays H
FIR - Bazata, Debbra D
IR  - Bazata DD
FIR - Gavin, James R 3rd
IR  - Gavin JR 3rd
FIR - Green, Andrew J
IR  - Green AJ
FIR - Lewis, Sandra J
IR  - Lewis SJ
FIR - Reed, Michael L
IR  - Reed ML
FIR - Rodbard, Helena W
IR  - Rodbard HW
EDAT- 2012/08/25 06:00
MHDA- 2013/04/10 06:00
PMCR- 2012/08/21
CRDT- 2012/08/25 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PHST- 2012/08/21 00:00 [pmc-release]
AID - 1477-7525-10-99 [pii]
AID - 10.1186/1477-7525-10-99 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2012 Aug 21;10:99. doi: 10.1186/1477-7525-10-99.