PMID- 22917527
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20211021
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 235
IP  - 2
DP  - 2012 Dec 1
TI  - Fos expression in the prefrontal cortex and ventral striatum after exposure to a 
      free-operant timing schedule.
PG  - 273-9
LID - S0166-4328(12)00527-X [pii]
LID - 10.1016/j.bbr.2012.08.009 [doi]
AB  - It has been proposed that cortico-striato-thalamo-cortical circuits that 
      incorporate the prefrontal cortex and corpus striatum regulate interval timing 
      behaviour. In the present experiment regional Fos expression was compared between 
      rats trained under an immediate timing schedule, the free-operant psychophysical 
      procedure (FOPP), which entails temporally regulated switching between two 
      operanda, and a yoked variable-interval (VI) schedule matched to the timing task 
      for food deprivation level, reinforcement rate and overall response rate. The 
      density of Fos-positive neurones (counts mm(-2)) in the orbital prefrontal cortex 
      (OPFC) and the shell of the nucleus accumbens (AcbS) was greater in rats exposed 
      to the FOPP than in rats exposed to the VI schedule, suggesting a greater 
      activation of these areas during the performance of the former task. The 
      enhancement of Fos expression in the OPFC is consistent with previous findings 
      with both immediate and retrospective timing schedules. Enhanced Fos expression 
      in the AcbS was previously found in retrospective timing schedules based on 
      conditional discrimination tasks, but not in a single-operandum immediate timing 
      schedule, the fixed-interval peak procedure. It is suggested that the ventral 
      striatum may be engaged during performance on timing schedules that entail 
      operant choice, irrespective of whether they belong to the immediate or 
      retrospective categories.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Valencia-Torres, L
AU  - Valencia-Torres L
AD  - Psychopharmacology Section, Division of Psychiatry, University of Nottingham, UK. 
      lourdes_vt@hotmail.com
FAU - Olarte-Sanchez, C M
AU  - Olarte-Sanchez CM
FAU - Body, S
AU  - Body S
FAU - Cheung, T H C
AU  - Cheung TH
FAU - Fone, K C F
AU  - Fone KC
FAU - Bradshaw, C M
AU  - Bradshaw CM
FAU - Szabadi, E
AU  - Szabadi E
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Oncogene Proteins v-fos)
SB  - IM
MH  - Animals
MH  - Basal Ganglia/*metabolism
MH  - Cell Count
MH  - Conditioning, Operant/*physiology
MH  - Female
MH  - Food Deprivation/physiology
MH  - Gene Expression Regulation/*physiology
MH  - Oncogene Proteins v-fos/*metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reinforcement Schedule
MH  - Reinforcement, Psychology
MH  - Time Factors
MH  - Time Perception/*physiology
PMC - PMC3657143
EDAT- 2012/08/25 06:00
MHDA- 2013/02/26 06:00
PMCR- 2012/12/01
CRDT- 2012/08/25 06:00
PHST- 2012/07/08 00:00 [received]
PHST- 2012/08/06 00:00 [revised]
PHST- 2012/08/08 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - S0166-4328(12)00527-X [pii]
AID - 10.1016/j.bbr.2012.08.009 [doi]
PST - ppublish
SO  - Behav Brain Res. 2012 Dec 1;235(2):273-9. doi: 10.1016/j.bbr.2012.08.009. Epub 
      2012 Aug 16.