PMID- 22917963
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20121030
IS  - 1873-4022 (Electronic)
IS  - 1873-4022 (Linking)
VI  - 37
IP  - 4
DP  - 2012 Winter
TI  - Larynx-sparing techniques using intensity-modulated radiation therapy for 
      oropharyngeal cancer.
PG  - 383-6
LID - S0958-3947(12)00056-8 [pii]
LID - 10.1016/j.meddos.2012.02.004 [doi]
AB  - The purpose of the current study was to explore whether the laryngeal dose can be 
      reduced by using 2 intensity-modulated radiation therapy (IMRT) techniques: 
      whole-neck field IMRT technique (WF-IMRT) vs. junctioned IMRT (J-IMRT). The 
      effect on planning target volumes (PTVs) coverage and laryngeal sparing was 
      evaluated. WF-IMRT technique consisted of a single IMRT plan, including the 
      primary tumor and the superior and inferior neck to the level of the clavicular 
      heads. The larynx was defined as an organ at risk extending superiorly to cover 
      the arytenoid cartilages and inferiorly to include the cricoid cartilage. The 
      J-IMRT technique consisted of an IMRT plan for the primary tumor and the superior 
      neck, matched to conventional antero-posterior opposing lower neck fields at the 
      level of the thyroid notch. A central block was used for the anterior lower neck 
      field at the level of the larynx to restrict the dose to the larynx. Ten 
      oropharyngeal cancer cases were analyzed. Both the primary site and bilateral 
      regional lymphatics were included in the radiotherapy targets. The averaged V95 
      for the PTV57.6 was 99.2% for the WF-IMRT technique compared with 97.4% (p = 
      0.02) for J-IMRT. The averaged V95 for the PTV64 was 99.9% for the WF-IMRT 
      technique compared with 98.9% (p = 0.02) for J-IMRT and the averaged V95 for the 
      PT70 was 100.0% for WF-IMRT technique compared with 99.5% (p = 0.04) for J-IMRT. 
      The averaged mean laryngeal dose was 18 Gy with both techniques. The averaged 
      mean doses within the matchline volumes were 69.3 Gy for WF-MRT and 66.2 Gy for 
      J-IMRT (p = 0.03). The WF-IMRT technique appears to offer an optimal coverage of 
      the target volumes and a mean dose to the larynx similar with J-IMRT and should 
      be further evaluated in clinical trials.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Bar Ad, Voichita
AU  - Bar Ad V
AD  - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 
      USA. voichita.bar-ad@jeffersonhospital.org
FAU - Lin, Haibo
AU  - Lin H
FAU - Hwang, Wei-Ting
AU  - Hwang WT
FAU - Deville, Curtiland
AU  - Deville C
FAU - Dutta, Pinaki R
AU  - Dutta PR
FAU - Tochner, Zelig
AU  - Tochner Z
FAU - Both, Stefan
AU  - Both S
LA  - eng
PT  - Journal Article
DEP - 20120821
PL  - United States
TA  - Med Dosim
JT  - Medical dosimetry : official journal of the American Association of Medical 
      Dosimetrists
JID - 8908862
SB  - IM
MH  - Carcinoma, Squamous Cell
MH  - Humans
MH  - Larynx/*radiation effects
MH  - Organ Sparing Treatments/*methods
MH  - Organs at Risk/*radiation effects
MH  - Oropharyngeal Neoplasms/*radiotherapy
MH  - Radiometry/*methods
MH  - *Radiotherapy Dosage
MH  - Radiotherapy, Conformal/*methods
MH  - Treatment Outcome
EDAT- 2012/08/25 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/08/25 06:00
PHST- 2010/12/05 00:00 [received]
PHST- 2011/11/27 00:00 [revised]
PHST- 2012/02/08 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - S0958-3947(12)00056-8 [pii]
AID - 10.1016/j.meddos.2012.02.004 [doi]
PST - ppublish
SO  - Med Dosim. 2012 Winter;37(4):383-6. doi: 10.1016/j.meddos.2012.02.004. Epub 2012 
      Aug 21.