PMID- 22918557
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20211021
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 113
IP  - 3
DP  - 2013 Mar
TI  - Effects of a high-carbohydrate versus high-protein meal on acute responses to 
      hypoxia at rest and exercise.
PG  - 691-702
LID - 10.1007/s00421-012-2472-z [doi]
AB  - A carbohydrate (CHO) solution consumed before exposure to hypoxia has been 
      reported to reduce arterial oxygen desaturation at rest. The purpose of this 
      study was to determine whether this effect occurred during exercise and when the 
      CHO load is part of a meal. Eleven male subjects (mean age 20.1 +/- 1.8 years, BMI 
      24.3 +/- 2.4 kg m(2)) consumed either a high-CHO (2,340 kJ, 70 % CHO, 12 % protein) 
      or an isoenergetic high-protein (35 % CHO, 48 % protein) breakfast meal 60 min 
      before being exposed to 15 min of hypoxia (F(I)O(2) = 13.5 %) followed by 30 min 
      of exercise in hypoxia (60 % of VO(2)max). Saturation of oxygen via a pulse 
      oxymeter (SpO(2)), ventilatory parameters, substrate oxidation, interstitial 
      glucose concentrations, and heart rate variability (HRV) were monitored 
      continuously during the whole session. Results showed no effect from the type of 
      meal on SpO(2) at rest but a 3.1 +/- 0.4 % reduction of desaturation during 
      exercise (P < 0.005) compared to the high-protein version. This was associated 
      with higher levels of ventilation (P < 0.05) and CO(2) production (P < 0.01). 
      Glucose oxidation was higher after the high-CHO than the high-protein breakfast 
      over the whole session (+19.4 + 4.0 %, P < 0.0001), whereas the interstitial 
      glucose levels were increased only at rest (P < 0.001). HRV indices were not 
      different between conditions. In conclusion, a high-CHO meal consumed prior to 
      moderate exercise in hypoxia condition reduced oxygen desaturation compared to a 
      high-protein meal.
FAU - Charlot, Keyne
AU  - Charlot K
AD  - EA2363, Laboratoire des Reponses Cellulaires et Fonctionnelles a l'Hypoxie, UFR 
      SMBH, Universite Paris 13, Sorbonne Paris Cite, 74 rue Marcel Cachin, 93017 
      Bobigny Cedex, France.
FAU - Pichon, Aurelien
AU  - Pichon A
FAU - Richalet, Jean-Paul
AU  - Richalet JP
FAU - Chapelot, Didier
AU  - Chapelot D
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120824
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Proteins/*administration & dosage
MH  - Exercise/*physiology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Meals
MH  - Osmolar Concentration
MH  - *Oxygen Consumption
MH  - Rest/*physiology
MH  - Single-Blind Method
MH  - Time Factors
MH  - Young Adult
EDAT- 2012/08/25 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/07/28 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 10.1007/s00421-012-2472-z [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2013 Mar;113(3):691-702. doi: 10.1007/s00421-012-2472-z. Epub 
      2012 Aug 24.