PMID- 22918638
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20130109
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Sep 14
TI  - Multifocal electroretinography in eyes with reticular pseudodrusen.
PG  - 6263-70
LID - 10.1167/iovs.12-10094 [doi]
AB  - PURPOSE: The aim of our study was to evaluate the impact of reticular 
      pseudodrusen (RPD) on retinal function by multifocal electroretinography (mfERG), 
      and combined simultaneous confocal scanning laser ophthalmoscopy (cSLO) and 
      spectral-domain optical coherence tomography (SD-OCT). METHODS: We included 19 
      eyes of 15 patients with RPD in the posterior pole and no other phenotypic 
      retinal alteration were included (7 females and 8 males, age 77.2 +/- 5.1 years) as 
      well as 24 eyes of 17 healthy control subjects (7 females and 10 males, age 73.2 
      +/- 5.9 years). All patients underwent fundus photography, SD-OCT, fluorescence 
      angiography (FA), fundus autofluorescence, and near-infrared reflectance cSLO. 
      mfERG measurements were performed by stimulating the retina by a field of 103 
      hexagons covering an area of approximately 30 degrees . Amplitudes and latencies of focal 
      retinal responses obtained at affected and nonaffected sites of RPD eyes and 
      retinal responses of healthy control subjects were compared. RESULTS: In all 
      included study eyes, RPD stages 1-3 could be demonstrated clearly in SD-OCT, FA, 
      and cSLO. The mean amplitudes measured in the areas affected by RPD were 12.5 to 
      53.1 nV/deg(2) (control group 19.4-50.1 nV/deg(2)). The mean latencies were 33.2 to 
      41.3 ms (control group 33.6-39.7 ms). mfERG amplitudes and latencies of retinal 
      areas affected by RPD were not altered significantly when compared to 
      corresponding nonaffected areas. CONCLUSIONS: mfERG measurements did not show a 
      definite influence on electrophysiologic activity in retinal areas affected 
      exclusively with RPD.
FAU - Alten, Florian
AU  - Alten F
AD  - Department of Ophthalmology, University of Muenster Medical Center, Muenster, 
      Germany. florian.alten@ukmuenster.de
FAU - Heiduschka, Peter
AU  - Heiduschka P
FAU - Clemens, Christoph R
AU  - Clemens CR
FAU - Eter, Nicole
AU  - Eter N
LA  - eng
PT  - Journal Article
DEP - 20120914
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Electroretinography/methods
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macula Lutea/physiopathology
MH  - Male
MH  - Retinal Drusen/*physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2012/08/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - iovs.12-10094 [pii]
AID - 10.1167/iovs.12-10094 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Sep 14;53(10):6263-70. doi: 
      10.1167/iovs.12-10094.