PMID- 22919373
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20230502
IS  - 1687-5273 (Electronic)
IS  - 1687-5265 (Print)
VI  - 2012
DP  - 2012
TI  - Interspike interval based filtering of directional selective retinal ganglion 
      cells spike trains.
PG  - 918030
LID - 10.1155/2012/918030 [doi]
LID - 918030
AB  - The information regarding visual stimulus is encoded in spike trains at the 
      output of retina by retinal ganglion cells (RGCs). Among these, the directional 
      selective cells (DSRGC) are signaling the direction of stimulus motion. DSRGCs' 
      spike trains show accentuated periods of short interspike intervals (ISIs) framed 
      by periods of isolated spikes. Here we use two types of visual stimulus, white 
      noise and drifting bars, and show that short ISI spikes of DSRGCs spike trains 
      are more often correlated to their preferred stimulus feature (that is, the 
      direction of stimulus motion) and carry more information than longer ISI spikes. 
      Firstly, our results show that correlation between stimulus and recorded neuronal 
      response is best at short ISI spiking activity and decrease as ISI becomes 
      larger. We then used grating bars stimulus and found that as ISI becomes shorter 
      the directional selectivity is better and information rates are higher. 
      Interestingly, for the less encountered type of DSRGC, known as ON-DSRGC, short 
      ISI distribution and information rates revealed consistent differences when 
      compared with the other directional selective cell type, the ON-OFF DSRGC. 
      However, these findings suggest that ISI-based temporal filtering integrates a 
      mechanism for visual information processing at the output of retina toward higher 
      stages within early visual system.
FAU - Martiniuc, Aurel Vasile
AU  - Martiniuc AV
AD  - Computer Science Department VI, Technical University Munich, 85748 Garching, 
      Germany. martiniv@in.tum.de
FAU - Knoll, Alois
AU  - Knoll A
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - United States
TA  - Comput Intell Neurosci
JT  - Computational intelligence and neuroscience
JID - 101279357
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Models, Neurological
MH  - Motion
MH  - Neurons/*physiology
MH  - *Ocular Physiological Phenomena
MH  - Rabbits
MH  - Retinal Ganglion Cells/*physiology
MH  - Time Factors
PMC - PMC3419397
EDAT- 2012/08/25 06:00
MHDA- 2012/12/21 06:00
PMCR- 2012/08/02
CRDT- 2012/08/25 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/06/10 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
PHST- 2012/08/02 00:00 [pmc-release]
AID - 10.1155/2012/918030 [doi]
PST - ppublish
SO  - Comput Intell Neurosci. 2012;2012:918030. doi: 10.1155/2012/918030. Epub 2012 Aug 
      2.