PMID- 22920078
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20220309
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 109
IP  - 3
DP  - 2012 Sep
TI  - Profilin cross-reactive panallergen causes latex sensitization in the pediatric 
      population allergic to pollen.
PG  - 215-9
LID - 10.1016/j.anai.2012.07.003 [doi]
AB  - BACKGROUND: Component-resolved diagnostics (CRD) has been demonstrated to be an 
      excellent new tool for improving the current diagnosis of allergies, and it 
      allows differentiation between polysensitization and cross-reactivity. OBJECTIVE: 
      To demonstrate the role of cross-reactive pollen allergens in pediatric patients 
      living in areas with large amounts of airborne grass pollen grains who are 
      sensitive to grass pollen and latex. METHODS: Serum samples were obtained from 
      106 children between 3 and 14 years of age diagnosed with allergies to pollen 
      based on clinical history, skin prick tests, and specific immunoglobulin E (IgE). 
      None of them had allergy symptoms to latex or fruits. From these 106 children, 56 
      patients revealed positive results to Phleum-specific major allergens but not to 
      cross-reactive allergens. The other 50 patients who showed positive specific IgE 
      to Phleum-specific major allergens and to cross-reactive pollen allergens also 
      showed positive results to latex allergens. CRD was carried out by specific IgE 
      quantification using a fluoro-enzyme immunoassay (ImmunoCAPT System). RESULTS: 
      Results demonstrated a positive significant relationship between the specific IgE 
      to Hev b 8 and Phl p 12 and also between the specific IgE to Hev b 8 and latex 
      extract in the group of patients sensitized to species-specific and 
      cross-reactive Phleum allergens. Positive significant relationships were also 
      found between profilin and avocado or peach sensitizations. No other latex 
      allergens gave positive results. CONCLUSION: The apparent sensitization to latex 
      in pediatric patients allergic to grass pollen is caused by the cross-reactive 
      profilin panallergen; however, it is appears not to be clinically relevant.
CI  - Copyright (c) 2012 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Casquete-Roman, Encarnacion
AU  - Casquete-Roman E
AD  - Service of Clinical Analysis and Biochemistry, Complejo Hospitalario de Leon, 
      Spain.
FAU - Rosado-Gil, Tomas
AU  - Rosado-Gil T
FAU - Postigo, Idoia
AU  - Postigo I
FAU - Guisantes, Jorge A
AU  - Guisantes JA
FAU - Fernandez, Maribel
AU  - Fernandez M
FAU - Torres, Hector-Enrique
AU  - Torres HE
FAU - Martinez-Quesada, Jorge
AU  - Martinez-Quesada J
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Hev b 8 allergen, Hevea brasiliensis)
RN  - 0 (Latex)
RN  - 0 (Phl p 12 allergen, timothy grass)
RN  - 0 (Profilins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Antigens, Plant/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross Reactions/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/etiology/*immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Latex/*immunology
MH  - Latex Hypersensitivity/*etiology/immunology
MH  - Male
MH  - Poaceae/*immunology
MH  - Pollen/*immunology
MH  - Profilins/*immunology
EDAT- 2012/08/28 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/04/04 00:00 [received]
PHST- 2012/06/26 00:00 [revised]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1081-1206(12)00501-7 [pii]
AID - 10.1016/j.anai.2012.07.003 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2012 Sep;109(3):215-9. doi: 
      10.1016/j.anai.2012.07.003. Epub 2012 Aug 1.