PMID- 22921929
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 235
IP  - 2
DP  - 2012 Dec 1
TI  - Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in 
      the novelty-suppressed feeding test.
PG  - 287-92
LID - S0166-4328(12)00534-7 [pii]
LID - 10.1016/j.bbr.2012.08.016 [doi]
AB  - Accumulated evidence indicates that metabotropic glutamate 5 (mGlu5) receptor 
      blockade exerts antidepressant-like and anxiolytic-like effects in several animal 
      models. The novelty-suppressed feeding (NSF) test is used to measure 
      anxiety-induced hypophagia in rodents. Anxiogenic-like behavior can be 
      counteracted by acute treatment with anxiolytics or chronic treatment with 
      antidepressants. The objective of the present study was to investigate the effect 
      of an mGlu5 receptor antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), 
      using the NSF test and to investigate the mechanisms underlying the effects of 
      MPEP. The administration of MPEP at 1 h prior to testing significantly shortened 
      the latency period until feed (an acute effect), and this effect lasted for 24 h 
      (a sustained effect), similar to the results observed using the 
      N-methyl-D-aspartate receptor antagonist ketamine. Pretreatment with a protein 
      synthesis inhibitor, anisomycin, blocked the sustained, but not the acute, 
      effects of MPEP, suggesting the involvement of new protein synthesis in the 
      sustained effect of MPEP. In addition, the sustained effect of MPEP in the NSF 
      test was partially abolished by pretreatment with a mammalian target of rapamycin 
      (mTOR) antagonist, rapamycin. In contrast, a tropomyosin-related kinase, the 
      tyrosine kinase inhibitor K252a, did not counteract the sustained effects of MPEP 
      in this test. Taken together, these results are the first report to demonstrate 
      that the blockade of the mGlu5 receptor exerted acute and sustained effects in 
      the NSF test and that new protein synthesis may contribute to the sustained 
      effects of MPEP, which may not mediate brain-derived neurotrophic factor-mTOR 
      signaling.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Iijima, Michihiko
AU  - Iijima M
AD  - Discovery Pharmacology I, Molecular Function and Pharmacology Laboratories, 
      Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 
      331-9530, Japan. m.iijima@po.rd.taisho.co.jp
FAU - Fukumoto, Kenichi
AU  - Fukumoto K
FAU - Chaki, Shigeyuki
AU  - Chaki S
LA  - eng
PT  - Journal Article
DEP - 20120816
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Pyridines)
RN  - 7VC0YVI27Y (6-methyl-2-(phenylethynyl)pyridine)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - O4L1XPO44W (Fluvoxamine)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Anti-Anxiety Agents/*administration & dosage
MH  - Anxiety/diagnosis/*drug therapy
MH  - Carbazoles/administration & dosage
MH  - Diazepam/therapeutic use
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Enzyme Inhibitors/administration & dosage
MH  - Exploratory Behavior/*drug effects
MH  - Feeding Behavior/*drug effects
MH  - Fluvoxamine/therapeutic use
MH  - Immunosuppressive Agents/pharmacology
MH  - Indole Alkaloids/administration & dosage
MH  - *Inhibition, Psychological
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pyridines/*administration & dosage
MH  - Reaction Time/drug effects
MH  - Sirolimus/pharmacology
MH  - Time Factors
EDAT- 2012/08/28 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/08/07 00:00 [revised]
PHST- 2012/08/12 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - S0166-4328(12)00534-7 [pii]
AID - 10.1016/j.bbr.2012.08.016 [doi]
PST - ppublish
SO  - Behav Brain Res. 2012 Dec 1;235(2):287-92. doi: 10.1016/j.bbr.2012.08.016. Epub 
      2012 Aug 16.