PMID- 22922121
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220330
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic 
      factor and other trophic factors.
PG  - 214-27
LID - S0306-4522(12)00861-5 [pii]
LID - 10.1016/j.neuroscience.2012.08.034 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a secreted protein that has been 
      linked to numerous aspects of plasticity in the central nervous system (CNS). 
      Stress-induced remodeling of the hippocampus, prefrontal cortex and amygdala is 
      coincident with changes in the levels of BDNF, which has been shown to act as a 
      trophic factor facilitating the survival of existing and newly born neurons. 
      Initially, hippocampal atrophy after chronic stress was associated with reduced 
      BDNF, leading to the hypothesis that stress-related learning deficits resulted 
      from suppressed hippocampal neurogenesis. However, recent evidence suggests that 
      BDNF also plays a rapid and essential role in regulating synaptic plasticity, 
      providing another mechanism through which BDNF can modulate learning and memory 
      after a stressful event. Numerous reports have shown BDNF levels are highly 
      dynamic in response to stress, and not only vary across brain regions but also 
      fluctuate rapidly, both immediately after a stressor and over the course of a 
      chronic stress paradigm. Yet, BDNF alone is not sufficient to effect many of the 
      changes observed after stress. Glucocorticoids and other molecules have been 
      shown to act in conjunction with BDNF to facilitate both the morphological and 
      molecular changes that occur, particularly changes in spine density and gene 
      expression. This review briefly summarizes the evidence supporting BDNF's role as 
      a trophic factor modulating neuronal survival, and will primarily focus on the 
      interactions between BDNF and other systems within the brain to facilitate 
      synaptic plasticity. This growing body of evidence suggests a more nuanced role 
      for BDNF in stress-related learning and memory, where it acts primarily as a 
      facilitator of plasticity and is dependent upon the coactivation of 
      glucocorticoids and other factors as the determinants of the final cellular 
      response.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Gray, J D
AU  - Gray JD
AD  - Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The 
      Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. 
      jason.gray@rockefeller.edu
FAU - Milner, T A
AU  - Milner TA
FAU - McEwen, B S
AU  - McEwen BS
LA  - eng
GR  - R37 MH041256/MH/NIMH NIH HHS/United States
GR  - R21 AG039850/AG/NIA NIH HHS/United States
GR  - R01 DA008259/DA/NIDA NIH HHS/United States
GR  - AG039850/AG/NIA NIH HHS/United States
GR  - R01 HL098351/HL/NHLBI NIH HHS/United States
GR  - R01 MH041256/MH/NIMH NIH HHS/United States
GR  - P01 HL096571/HL/NHLBI NIH HHS/United States
GR  - AG016765/AG/NIA NIH HHS/United States
GR  - DA08259/DA/NIDA NIH HHS/United States
GR  - HL096571/HL/NHLBI NIH HHS/United States
GR  - MH41256/MH/NIMH NIH HHS/United States
GR  - HL098351/HL/NHLBI NIH HHS/United States
GR  - P01 AG016765/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120823
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Glucocorticoids/*metabolism
MH  - Humans
MH  - Nerve Growth Factors/metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Stress, Psychological/metabolism
PMC - PMC3743657
MID - NIHMS402824
EDAT- 2012/08/28 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/06/03
CRDT- 2012/08/28 06:00
PHST- 2012/06/29 00:00 [received]
PHST- 2012/08/15 00:00 [revised]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/06/03 00:00 [pmc-release]
AID - S0306-4522(12)00861-5 [pii]
AID - 10.1016/j.neuroscience.2012.08.034 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:214-27. doi: 10.1016/j.neuroscience.2012.08.034. 
      Epub 2012 Aug 23.