PMID- 22922215
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20220409
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 326
IP  - 2
DP  - 2012 Dec 30
TI  - The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced 
      E-cadherin down-regulation and cell proliferation in ovarian cancer cells.
PG  - 191-8
LID - S0304-3835(12)00504-6 [pii]
LID - 10.1016/j.canlet.2012.08.016 [doi]
AB  - Insulin-like growth factor 1 (IGF1) is produced by ovarian cancer cells and it 
      has been suggested that it plays an important role in tumor progression. In this 
      study, we report that IGF1 treatment down-regulated E-cadherin by up-regulating 
      E-cadherin transcriptional repressors, Snail and Slug, in human ovarian cancer 
      cells. The pharmacological inhibition of phosphatidylinositol-3-kinase (PI3K) and 
      mammalian target of rapamycin (mTOR) suggests that PI3K/Akt/mTOR signaling is 
      required for IGF1-induced E-cadherin down-regulation. Moreover, IGF1 up-regulated 
      Snail and Slug expression via the PI3K/Akt/mTOR signaling pathway. Finally, 
      IGF1-induced cell proliferation was abolished by inhibiting PI3K/Akt/mTOR 
      signaling. This study demonstrates a novel mechanism in which IGF1 down-regulates 
      E-cadherin expression through the activation of PI3K/Akt/mTOR signaling and the 
      up-regulation of Snail and Slug in human ovarian cancer cells.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Lau, Man-Tat
AU  - Lau MT
AD  - Department of Obstetrics and Gynecology, Child and Family Research Institute, 
      University of British Columbia, Vancouver, BC, Canada.
FAU - Leung, Peter C K
AU  - Leung PC
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120821
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Cadherins)
RN  - 0 (DNA Primers)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Base Sequence
MH  - Cadherins/*metabolism
MH  - *Cell Proliferation
MH  - DNA Primers
MH  - *Down-Regulation
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*physiology
MH  - Ovarian Neoplasms/*metabolism/pathology
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Pregnancy
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2012/08/28 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/08/14 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0304-3835(12)00504-6 [pii]
AID - 10.1016/j.canlet.2012.08.016 [doi]
PST - ppublish
SO  - Cancer Lett. 2012 Dec 30;326(2):191-8. doi: 10.1016/j.canlet.2012.08.016. Epub 
      2012 Aug 21.