PMID- 22922663
OWN - NLM
STAT- MEDLINE
DCOM- 20140805
LR  - 20221207
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 23
IP  - 3
DP  - 2014 Mar
TI  - Incidence of deepening of the upper eyelid sulcus after topical use of travoprost 
      ophthalmic solution in Japanese.
PG  - 160-3
LID - 10.1097/IJG.0b013e31826a7e09 [doi]
AB  - PURPOSE: To investigate the incidence of deepening of the upper eyelid sulcus 
      (DUES) with topical use of travoprost in Japanese glaucoma patients. PATIENTS AND 
      METHODS: This prospective study enrolled 32 primary open-angle glaucoma Japanese 
      patients who had been treated topically with travoprost unilaterally for 6 months 
      at baseline, and started treatment in both eyes. The patients were observed 
      during outpatient visits at 2, 4, and 6 months. At every visit, the photographs 
      of both eyes and forehead were displayed randomly and the presence of DUES was 
      diagnosed when 3 examiners unanimously rated the case as positive. The patients 
      were also asked if they noticed any subjective symptom of DUES. Sex, refraction, 
      and intraocular pressure (IOP) were evaluated as potential risk factors. RESULTS: 
      DUES was identified objectively in 34% (11/32) of the patients after 2 months of 
      treatment, and in 53% (17/32) after 4 and 6 months of treatment. The incidence 
      was significantly higher in older patients (P<0.05), but not related to sex, 
      refraction, pretreatment and posttreatment IOP, and IOP reduction. Finally, 41% 
      (7/17) of patients with objectively diagnosed DUES noticed the presence of DUES 
      by themselves. No patient dropped out of the study because of DUES. CONCLUSIONS: 
      DUES is a common side effect of topical travoprost treatment in Japanese glaucoma 
      patients.
FAU - Maruyama, Katsuhiko
AU  - Maruyama K
AD  - *Department of Ophthalmology, Tokyo Medical University daggerYotsuya Shirato Eye 
      Clinic, Tokyo, Japan.
FAU - Shirato, Shiroaki
AU  - Shirato S
FAU - Tsuchisaka, Asako
AU  - Tsuchisaka A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Ophthalmic Solutions)
RN  - 4208238832 (Cloprostenol)
RN  - WJ68R08KX9 (Travoprost)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antihypertensive Agents/*adverse effects/therapeutic use
MH  - Asian People
MH  - Cloprostenol/adverse effects/*analogs & derivatives/therapeutic use
MH  - Eyelid Diseases/*chemically induced/diagnosis
MH  - Eyelids/*drug effects/pathology
MH  - Female
MH  - Glaucoma, Open-Angle/*drug therapy
MH  - Humans
MH  - Incidence
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Ophthalmic Solutions
MH  - Prospective Studies
MH  - Travoprost
EDAT- 2012/08/28 06:00
MHDA- 2014/08/06 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2014/08/06 06:00 [medline]
AID - 10.1097/IJG.0b013e31826a7e09 [doi]
PST - ppublish
SO  - J Glaucoma. 2014 Mar;23(3):160-3. doi: 10.1097/IJG.0b013e31826a7e09.