PMID- 22923493
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20221207
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 120
IP  - 15
DP  - 2012 Oct 11
TI  - HLA-DP genetic variation, proxies for early life immune modulation and childhood 
      acute lymphoblastic leukemia risk.
PG  - 3039-47
LID - 10.1182/blood-2012-01-404723 [doi]
AB  - The human leukocyte antigen (HLA) genes are candidate genetic susceptibility loci 
      for childhood acute lymphoblastic leukemia (ALL). We examined the effect of 
      HLA-DP genetic variation on risk and evaluated its potential interaction with 4 
      proxies for early immune modulation, including measures of infectious exposures 
      in infancy (presence of older siblings, daycare attendance, ear infections) and 
      breastfeeding. A total of 585 ALL cases and 848 controls were genotyped at the 
      HLA-DPA1 and DPB1 loci. Because of potential heterogeneity in effect by 
      race/ethnicity, we included only non-Hispanic white (47%) and Hispanic (53%) 
      children and considered these 2 groups separately in the analysis. Logistic 
      regression analyses showed an increased risk of ALL associated with 
      HLA-DPB1*01:01 (odds ratio [OR] = 1.43, 95% CI, 1.01-2.04) with no heterogeneity 
      by Hispanic ethnicity (P = .969). Analyses of DPB1 supertypes showed a marked 
      childhood ALL association with DP1, particularly for high-hyperdiploid ALL (OR = 
      1.83; 95% CI, 1.20-2.78). Evidence of interaction was found between DP1 and older 
      sibling (P = .036), and between DP1 and breastfeeding (P = .094), with both 
      showing statistically significant DP1 associations within the lower exposure 
      categories only. These findings support an immune mechanism in the etiology of 
      childhood ALL involving the HLA-DPB1 gene in the context of an insufficiently 
      modulated immune system.
FAU - Urayama, Kevin Y
AU  - Urayama KY
AD  - School of Public Health, University of California, Berkeley, CA 94704, USA. 
      kurayama@luke.or.jp
FAU - Chokkalingam, Anand P
AU  - Chokkalingam AP
FAU - Metayer, Catherine
AU  - Metayer C
FAU - Ma, Xiaomei
AU  - Ma X
FAU - Selvin, Steve
AU  - Selvin S
FAU - Barcellos, Lisa F
AU  - Barcellos LF
FAU - Wiemels, Joseph L
AU  - Wiemels JL
FAU - Wiencke, John K
AU  - Wiencke JK
FAU - Taylor, Malcolm
AU  - Taylor M
FAU - Brennan, Paul
AU  - Brennan P
FAU - Dahl, Gary V
AU  - Dahl GV
FAU - Moonsamy, Priscilla
AU  - Moonsamy P
FAU - Erlich, Henry A
AU  - Erlich HA
FAU - Trachtenberg, Elizabeth
AU  - Trachtenberg E
FAU - Buffler, Patricia A
AU  - Buffler PA
LA  - eng
GR  - R03 CA125823/CA/NCI NIH HHS/United States
GR  - P42ES0470518/ES/NIEHS NIH HHS/United States
GR  - R01ES09137/ES/NIEHS NIH HHS/United States
GR  - R01 ES009137/ES/NIEHS NIH HHS/United States
GR  - R03CA125823/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120824
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPA1 antigen)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation/*genetics
MH  - Genotype
MH  - HLA-DP alpha-Chains/*genetics
MH  - HLA-DP beta-Chains/*genetics
MH  - Hispanic or Latino/genetics
MH  - Humans
MH  - *Immunologic Factors
MH  - Infant
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/ethnology/*etiology
MH  - Prognosis
MH  - Risk Factors
MH  - White People/genetics
MH  - Young Adult
PMC - PMC3471514
EDAT- 2012/08/28 06:00
MHDA- 2013/01/18 06:00
PMCR- 2013/10/11
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
PHST- 2013/10/11 00:00 [pmc-release]
AID - S0006-4971(20)46308-6 [pii]
AID - 2012/404723 [pii]
AID - 10.1182/blood-2012-01-404723 [doi]
PST - ppublish
SO  - Blood. 2012 Oct 11;120(15):3039-47. doi: 10.1182/blood-2012-01-404723. Epub 2012 
      Aug 24.