PMID- 22923506
OWN - NLM
STAT- MEDLINE
DCOM- 20130412
LR  - 20211021
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 113
IP  - 9
DP  - 2012 Nov
TI  - 55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: 
      role of HIF-1.
PG  - 1343-52
LID - 10.1152/japplphysiol.00843.2012 [doi]
AB  - When exposed to chronic hypoxia (CH), the pulmonary circulation responds with 
      enhanced contraction and vascular remodeling, resulting in elevated pulmonary 
      arterial pressures. Our work has identified CH-induced alterations in the 
      expression and activity of several ion channels and transporters in pulmonary 
      vascular smooth muscle that contribute to the development of hypoxic pulmonary 
      hypertension and uncovered a critical role for the transcription factor 
      hypoxia-inducible factor-1 (HIF-1) in mediating these responses. Current work is 
      focused on the regulation of HIF in the chronically hypoxic lung and evaluation 
      of the potential for pharmacological inhibitors of HIF to prevent, reverse, or 
      slow the progression of pulmonary hypertension.
FAU - Shimoda, Larissa A
AU  - Shimoda LA
AD  - Division of Pulmonary and Critical Care Medicine, Department of Medicine, The 
      Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. 
      shimodal@welch.jhu.edu
LA  - eng
PT  - Lecture
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120823
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Potassium Channels)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Hypertension, Pulmonary/etiology/physiopathology/prevention & control
MH  - Hypoxia/complications/drug therapy/*physiopathology
MH  - Hypoxia-Inducible Factor 1/antagonists & inhibitors/*physiology
MH  - Lung/physiopathology
MH  - Muscle, Smooth, Vascular/physiopathology
MH  - Potassium Channels/metabolism
MH  - Pulmonary Artery/physiopathology
MH  - Pulmonary Circulation/*physiology
PMC - PMC3524672
EDAT- 2012/08/28 06:00
MHDA- 2013/04/13 06:00
PMCR- 2013/11/01
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/04/13 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - japplphysiol.00843.2012 [pii]
AID - JAPPL-00843-2012 [pii]
AID - 10.1152/japplphysiol.00843.2012 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2012 Nov;113(9):1343-52. doi: 
      10.1152/japplphysiol.00843.2012. Epub 2012 Aug 23.