PMID- 22923897
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220331
IS  - 1998-393X (Electronic)
IS  - 0973-029X (Print)
IS  - 0973-029X (Linking)
VI  - 16
IP  - 2
DP  - 2012 May
TI  - Pathophysiology of Langerhans cells.
PG  - 239-44
LID - 10.4103/0973-029X.99077 [doi]
AB  - Langerhans cells (LCs) were first described by Paul Langerhans, in 1868, as 
      dendritically shaped cells, which were located in the squamous epithelia of 
      epidermis. Later on, these cells were identified in all stratified squamous 
      epithelium of mammals. Dendritic cells (DCs) play an important role in local 
      defense mechanisms in the epithelium. LCs are situated usually in the suprabasal 
      layer of stratified squamous epithelia of oral mucosa and epidermis of skin. They 
      constitute 3% of the cell population in epidermis. LCs are thought to act as 
      antigen presenting cells (APCs) during initiation of immune responses. With the 
      help of APCs, the lymphocytes are able to recognize and respond to specific 
      microbes. In this paper we have reviewed the origin, distribution, demonstration 
      and mechanism of action of LCs and their role in different pathological 
      conditions.
FAU - Jaitley, Shweta
AU  - Jaitley S
AD  - Department of Oral Pathology and Microbiology, K D Dental College and Hospital, 
      Mathura, Uttar Pradesh, India.
FAU - Saraswathi, Tr
AU  - Saraswathi T
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Oral Maxillofac Pathol
JT  - Journal of oral and maxillofacial pathology : JOMFP
JID - 101227995
PMC - PMC3424941
OTO - NOTNLM
OT  - Antigen presenting cells
OT  - Langerhans cells
OT  - clear cells
OT  - dendritic cells
COIS- Conflict of Interest: None declared.
EDAT- 2012/08/28 06:00
MHDA- 2012/08/28 06:01
PMCR- 2012/05/01
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/08/28 06:01 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - JOMFP-16-239 [pii]
AID - 10.4103/0973-029X.99077 [doi]
PST - ppublish
SO  - J Oral Maxillofac Pathol. 2012 May;16(2):239-44. doi: 10.4103/0973-029X.99077.