PMID- 22924100
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 2008-2185 (Electronic)
IS  - 1735-2150 (Print)
IS  - 1735-2150 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Winter
TI  - Histologic Evaluation of Bone Healing Following Application of Anorganic Bovine 
      Bone and beta-tricalcium Phosphate in Rabbit Calvaria.
PG  - 35-40
AB  - OBJECTIVE: Both anorganic bovine bone (ABB) and beta-tricalcium phosphate (beta-TCP) 
      are used in clinical practice as bone substitute materials, but there is limited 
      data comparing these two materials in standardized defects. The aim of this study 
      was to histologically evaluate the effectiveness of ABB and beta-TCP in the healing 
      of experimentally induced bone defects. MATERIALS AND METHODS: Eighteen bone 
      defects were created on the calvaria of six rabbits. In each animal, one defect 
      was left untreated and the other two were filled with ABB and beta-TCP. After one 
      month, histological sections were prepared. Type and vitality of newly formed 
      bone, percentage of new bone formation and residual material, thickness of 
      trabeculae, inflammation and foreign body reaction were assessed. RESULTS: The 
      newly formed osseous tissue was vital in all defects and consisted of woven and 
      lamellar bone. Mean percentages of new bone formation were 30.83+/-14.29%, 
      16.83+/-11.07% and 14.00+/-8.17% in beta-TCP, ABB and control groups, respectively and 
      the mean percentages of residual biomaterial were 24.17+/-14.01% and 36.50+/-8.43% in 
      beta-TCP and ABB groups, respectively. However, the differences were not 
      statistically significant (all ps>0.05). Inflammatory infiltration was 
      statistically higher in beta-TCP compared to the control group (p=0.025), but the 
      difference was not significant between beta-TCP and ABB groups (p=0.083). 
      Trabeculation thickness and foreign body reaction were not statistically 
      different between beta-TCP and ABB groups. CONCLUSION: beta-TCP and ABB were not 
      different with regard to the quantity and quality of newly formed osseous tissue. 
      However, inflammatory infiltration was higher in sites filled with beta-TCP.
FAU - Rokn, Ar
AU  - Rokn A
AD  - Dental Implant Research Center, School of Dentistry, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Moslemi, N
AU  - Moslemi N
FAU - Eslami, B
AU  - Eslami B
FAU - Abadi, H Khandagh
AU  - Abadi HK
FAU - Paknejad, M
AU  - Paknejad M
LA  - eng
PT  - Journal Article
DEP - 20120331
PL  - Iran
TA  - J Dent (Tehran)
JT  - Journal of dentistry (Tehran, Iran)
JID - 101233680
PMC - PMC3422061
OTO - NOTNLM
OT  - Anorganic Bovine Bone
OT  - Beta Tricalcium Phosphate
OT  - Bone Regeneration
OT  - Rabbits
OT  - Wound Healing
EDAT- 2012/08/28 06:00
MHDA- 2012/08/28 06:01
PMCR- 2012/01/01
CRDT- 2012/08/28 06:00
PHST- 2011/12/24 00:00 [received]
PHST- 2012/01/21 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/08/28 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - jod-9-35 [pii]
PST - ppublish
SO  - J Dent (Tehran). 2012 Winter;9(1):35-40. Epub 2012 Mar 31.