PMID- 22925354
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20151119
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 112
IP  - 2
DP  - 2013 Feb
TI  - A human experimental bone pain model.
PG  - 116-23
LID - 10.1111/bcpt.12002 [doi]
AB  - The aim of this study was to develop a human experimental bone pain model. 
      Fourteen healthy men were included in two study sessions. Pressure pain threshold 
      (PPT) was estimated using probes of different sizes. Computer-controlled and 
      hand-held algometry were applied to the skin area covering right and left medial 
      tibia before and after local anaesthesia (LA) of the skin and reproducibility was 
      evaluated. Pain experience (McGill questionnaire) was compared between healthy 
      volunteers and 12 patients with vertebral fractures. Computer-controlled 
      algometer: No differences in PPT between study sessions for 6 and 8-mm probes 
      (p = 0.43 and 0.32) were seen. There was a difference in PPT before and after LA 
      for the 6-mm probe (p = 0.008), but not for the 8-mm probe (p = 0.26). Hand-held 
      algometer: A difference in PPT between study sessions was observed for 4- and 
      8-mm probes (p = 0.03 and 0.007), but not for 2, 6 and 10-mm probes (p = 0.19, 
      0.05 and 0.25). No differences in PPT were seen before and after LA for 2, 4, 8 
      and 10-mm probes (p = 0.35, 0.15, 0.08 and 0.53), but LA significantly influenced 
      PPT with the 6-mm probe (p = 0.01). Similar words were chosen in the McGill pain 
      questionnaire by healthy volunteers and patients, qualitatively describing the 
      deep pain sensation. The pain evoked by hand-held algometer and the 2-mm probe 
      was not influenced by LA, and PPT was reproducible between sessions and is 
      recommended for studies of experimentally evoked bone-associated pain.
CI  - (c) 2012 The Authors Basic & Clinical Pharmacology & Toxicology (c) 2012 Nordic 
      Pharmacological Society.
FAU - Andresen, Trine
AU  - Andresen T
AD  - Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg Hospital, Aarhus 
      University, Aarhus, Denmark. tran@rn.dk
FAU - Pfeiffer-Jensen, Mogens
AU  - Pfeiffer-Jensen M
FAU - Brock, Christina
AU  - Brock C
FAU - Drewes, Asbjorn M
AU  - Drewes AM
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121020
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthesia, Local/*methods
MH  - Bone and Bones/*pathology
MH  - Case-Control Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/*etiology
MH  - Pain Measurement
MH  - Pain Threshold
MH  - Pressure
MH  - Reproducibility of Results
MH  - Spinal Fractures/*complications
MH  - Surveys and Questionnaires
MH  - Tibia
MH  - Young Adult
EDAT- 2012/08/29 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/01/05 00:00 [received]
PHST- 2012/08/09 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - 10.1111/bcpt.12002 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2013 Feb;112(2):116-23. doi: 10.1111/bcpt.12002. 
      Epub 2012 Oct 20.