PMID- 22925829
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20131121
IS  - 1873-3700 (Electronic)
IS  - 0031-9422 (Linking)
VI  - 84
DP  - 2012 Dec
TI  - Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in 
      the treatment type 2 diabetes mellitus.
PG  - 116-24
LID - S0031-9422(12)00348-2 [pii]
LID - 10.1016/j.phytochem.2012.07.025 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a rapidly expanding public epidemic and 
      frequently results in severe vascular complications. In an attempt to find 
      anti-diabetic agents, we report herein on the isolation, structural elucidation 
      and bioactivity of nine friedelane-type triterpenes (1-9) and twenty two known 
      ones (10-31) from the root barks of Celastrus vulcanicola and Maytenus jelskii. 
      Their structures were elucidated on the basis of spectroscopic analysis, 
      including 1D and 2D NMR techniques. Two compounds from this series (1 and 3) 
      exhibited increased insulin-mediated signalling, which suggests these friedelane 
      triterpenes have potential therapeutic use in insulin resistant states.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Ardiles, Alejandro E
AU  - Ardiles AE
AD  - Instituto Universitario de Bio-Organica Antonio Gonzalez and Departamento de 
      Quimica Organica, Universidad de La Laguna, Avenida Astrofisico Francisco Sanchez 
      2, 38206 La Laguna, Tenerife, Spain.
FAU - Gonzalez-Rodriguez, Agueda
AU  - Gonzalez-Rodriguez A
FAU - Nunez, Marvin J
AU  - Nunez MJ
FAU - Perestelo, Nayra R
AU  - Perestelo NR
FAU - Pardo, Virginia
AU  - Pardo V
FAU - Jimenez, Ignacio A
AU  - Jimenez IA
FAU - Valverde, Angela M
AU  - Valverde AM
FAU - Bazzocchi, Isabel L
AU  - Bazzocchi IL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120825
PL  - England
TA  - Phytochemistry
JT  - Phytochemistry
JID - 0151434
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Biological Products)
RN  - 0 (Triterpenes)
RN  - 0 (friedelane)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/isolation & 
      purification/*pharmacology/therapeutic use
MH  - Biological Products/chemistry/isolation & purification/*pharmacology/therapeutic 
      use
MH  - Celastrus/chemistry
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Drug Screening Assays, Antitumor
MH  - Humans
MH  - *Insulin Resistance
MH  - Maytenus/chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Plant Bark/chemistry
MH  - Plant Roots/chemistry
MH  - Stereoisomerism
MH  - Structure-Activity Relationship
MH  - Triterpenes/chemistry/isolation & purification/*pharmacology/therapeutic use
EDAT- 2012/08/29 06:00
MHDA- 2013/11/01 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2012/07/26 00:00 [revised]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - S0031-9422(12)00348-2 [pii]
AID - 10.1016/j.phytochem.2012.07.025 [doi]
PST - ppublish
SO  - Phytochemistry. 2012 Dec;84:116-24. doi: 10.1016/j.phytochem.2012.07.025. Epub 
      2012 Aug 25.