PMID- 22927496
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20220311
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 87
IP  - 4
DP  - 2012 Oct
TI  - Occurrence of Paracoccidioides lutzii in the Amazon region: description of two 
      cases.
PG  - 710-4
LID - 10.4269/ajtmh.2012.12-0340 [doi]
AB  - Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin 
      America, is known to be caused by at least four different phylogenetic lineages 
      within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and 
      Pb01-like group. Herein, we describe two cases of PCM in patients native from the 
      Amazon region. The disease was originally thought to have been caused by P. 
      brasiliensis. Despite the severity of the cases, sera from the patients were 
      negative in immunodiffusion tests using the standard exoantigen from P. 
      brasiliensis B-339. However, a positive response was recorded with an autologous 
      preparation of Paracoccidioides lutzii exoantigen. A phylogenetic approach based 
      on the gp43 and ARF loci revealed high similarity between our clinical isolates 
      and the Pb01-like group. The occurrence of PCM caused by P. lutzii in the 
      Brazilian Amazon (Para State) was thus proven. The incidence of PCM caused by P. 
      lutzii may be underestimated in northern Brazil.
FAU - Marques-da-Silva, Silvia Helena
AU  - Marques-da-Silva SH
AD  - Evandro Chagas Institute, Bacteriology and Mycology Section, Mycology Laboratory, 
      Ananindeua, Para, Brazil. marquespb339@gmail.com
FAU - Rodrigues, Anderson Messias
AU  - Rodrigues AM
FAU - de Hoog, G Sybren
AU  - de Hoog GS
FAU - Silveira-Gomes, Fabiola
AU  - Silveira-Gomes F
FAU - Camargo, Zoilo Pires de
AU  - Camargo ZP
LA  - eng
SI  - GENBANK/JX065607
SI  - GENBANK/JX065608
SI  - GENBANK/JX065609
SI  - GENBANK/JX065610
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120827
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antigens, Fungal)
RN  - 0 (DNA, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factor 1)
SB  - IM
MH  - ADP-Ribosylation Factor 1/genetics
MH  - Adult
MH  - Antigens, Fungal/genetics
MH  - Brazil/epidemiology
MH  - DNA, Fungal/analysis/isolation & purification
MH  - Female
MH  - Fungal Proteins/genetics
MH  - Glycoproteins/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Paracoccidioides/classification/*genetics/*isolation & purification
MH  - Paracoccidioidomycosis/*epidemiology/microbiology
MH  - Phylogeny
MH  - Sequence Analysis, DNA
PMC - PMC3516324
EDAT- 2012/08/29 06:00
MHDA- 2012/12/22 06:00
PMCR- 2013/10/03
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
PHST- 2013/10/03 00:00 [pmc-release]
AID - ajtmh.2012.12-0340 [pii]
AID - 10.4269/ajtmh.2012.12-0340 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2012 Oct;87(4):710-4. doi: 10.4269/ajtmh.2012.12-0340. Epub 
      2012 Aug 27.