PMID- 22928085
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20230429
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2012
DP  - 2012
TI  - Diet and aging.
PG  - 741468
LID - 10.1155/2012/741468 [doi]
LID - 741468
AB  - Nutrition has important long-term consequences for health that are not only 
      limited to the individual but can be passed on to the next generation. It can 
      contribute to the development and progression of chronic diseases thus effecting 
      life span. Caloric restriction (CR) can extend the average and maximum life span 
      and delay the onset of age-associated changes in many organisms. CR elicits 
      coordinated and adaptive stress responses at the cellular and whole-organism 
      level by modulating epigenetic mechanisms (e.g., DNA methylation, 
      posttranslational histone modifications), signaling pathways that regulate cell 
      growth and aging (e.g., TOR, AMPK, p53, and FOXO), and cell-to-cell signaling 
      molecules (e.g., adiponectin). The overall effect of these adaptive stress 
      responses is an increased resistance to subsequent stress, thus delaying 
      age-related changes and promoting longevity. In human, CR could delay many 
      diseases associated with aging including cancer, diabetes, atherosclerosis, 
      cardiovascular disease, and neurodegenerative diseases. As an alternative to CR, 
      several CR mimetics have been tested on animals and humans. At present, the most 
      promising alternatives to the use of CR in humans seem to be exercise, alone or 
      in combination with reduced calorie intake, and the use of plant-derived 
      polyphenol resveratrol as a food supplement.
FAU - Ribaric, Samo
AU  - Ribaric S
AD  - Institute of Pathophysiology, Medical Faculty, University of Ljubljana, 
      Ljubljana, Slovenia. samo.ribaric@mf.uni-lj.si
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120813
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
SB  - IM
MH  - Aging/genetics/*physiology
MH  - Animals
MH  - Caloric Restriction
MH  - *Diet
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Nutritional Status
PMC - PMC3425961
EDAT- 2012/08/29 06:00
MHDA- 2012/11/07 06:00
PMCR- 2012/08/13
CRDT- 2012/08/29 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/07/12 00:00 [revised]
PHST- 2012/07/16 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PHST- 2012/08/13 00:00 [pmc-release]
AID - 10.1155/2012/741468 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2012;2012:741468. doi: 10.1155/2012/741468. Epub 2012 Aug 
      13.