PMID- 22928624
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20211021
IS  - 1552-6569 (Electronic)
IS  - 1051-2284 (Print)
IS  - 1051-2284 (Linking)
VI  - 23
IP  - 1
DP  - 2013 Jan
TI  - High-level gait disorder: associations with specific white matter changes 
      observed on advanced diffusion imaging.
PG  - 39-46
LID - 10.1111/j.1552-6569.2012.00734.x [doi]
AB  - BACKGROUND AND PURPOSE: High-level gait disorder (HLGD) is a debilitating 
      disorder causing mobility decline in the elderly. Although its clinical 
      characteristics are well described, its anatomical and pathophysiological 
      underpinnings are poorly understood. This study examined the anatomical 
      distribution of white matter (WM) changes in patients with mild to moderate HLGD 
      of the cautious/disequilibrium type, using advanced magnetic resonance imaging 
      (MRI) methods. METHODS: Thirteen patients with HLGD, 9 elderly and 13 middle-aged 
      healthy controls were scanned using diffusion tensor imaging, Q-space imaging, 
      and conventional MRI. The regions of significant differences between the HLGD 
      group and the elderly control group were defined, and the mean fractional 
      anisotropy and displacement values of these areas were extracted. RESULTS: The 
      HLGD patients had lower fractional anisotropy and higher displacement values in 
      regions related to the motor system, including those along the corticospinal 
      tract and the superior cerebellar peduncles, as well as in cognitive and 
      affective-related areas, including the anterior limbs of the internal capsule and 
      the genu of the corpus callosum. CONCLUSIONS: The anatomical distribution 
      associated with HLGD of the cautious/disequilibrium type involves WM pathways 
      that convey motor-related, cognitive and affective-related functions. The 
      underlying pathological process leading to these changes most probably includes 
      demyelination.
CI  - Copyright (c) 2012 by the American Society of Neuroimaging.
FAU - Kafri, Michal
AU  - Kafri M
AD  - Functional Brain Center, Wohl Institute for Advanced Imaging, Sourasky Medical 
      Center, Tel Aviv, Israel.
FAU - Sasson, Efrat
AU  - Sasson E
FAU - Assaf, Yaniv
AU  - Assaf Y
FAU - Balash, Yaacov
AU  - Balash Y
FAU - Aiznstein, Orna
AU  - Aiznstein O
FAU - Hausdorff, Jeffrey M
AU  - Hausdorff JM
FAU - Giladi, Nir
AU  - Giladi N
LA  - eng
GR  - R01 AG014100/AG/NIA NIH HHS/United States
GR  - R01 HD039838/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20120828
PL  - United States
TA  - J Neuroimaging
JT  - Journal of neuroimaging : official journal of the American Society of 
      Neuroimaging
JID - 9102705
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Brain/*pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Gait Disorders, Neurologic/*pathology
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Male
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
PMC - PMC3514556
MID - NIHMS396599
EDAT- 2012/08/30 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/01/01
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.1111/j.1552-6569.2012.00734.x [doi]
PST - ppublish
SO  - J Neuroimaging. 2013 Jan;23(1):39-46. doi: 10.1111/j.1552-6569.2012.00734.x. Epub 
      2012 Aug 28.