PMID- 22930681
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20151119
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 96
IP  - 11
DP  - 2012 Nov
TI  - Comparison of aqueous concentrations of angiogenic and inflammatory cytokines in 
      diabetic macular oedema and macular oedema due to branch retinal vein occlusion.
PG  - 1426-30
LID - 10.1136/bjophthalmol-2012-301913 [doi]
AB  - AIMS: The involvement of cytokines in the aqueous humour is important in the 
      development and progression of diabetic macular oedema (DMO) and macular oedema 
      (MO) due to branch retinal vein occlusion (BRVO-MO). In this study, the 
      concentrations of cytokines in the aqueous humour of eyes with DMO and BRVO-MO 
      were measured and compared. METHODS: Prospective, observational case series. 
      Aqueous samples were obtained from 18 eyes with DMO (DMO group), 12 eyes with 
      BRVO-MO (BRVO-MO group), and 16 normal eyes (control group). The aqueous levels 
      of cytokines, including interleukin (IL)-2, IL-5, IL-6, IL-8, IL-12p70, IL-13, 
      monocytochemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha 
      (MIP-1alpha), platelet-derived growth factor-AA (PDGF)-AA, transforming growth 
      factor-alpha (TGF-alpha), interferon-gamma (IFN-gamma), epidermal growth factor, fibroblast 
      growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF), were 
      measured. RESULTS: The aqueous levels of IL-8, MCP-1, PDGF-AA and VEGF were 
      higher, and IL-13 was lower in the DMO group compared with the control group. The 
      aqueous levels of IL-8 and VEGF were higher in the BRVO-MO group than in the 
      control group. Compared with the IL-6 and MCP-1 levels in the BRVO-MO group, 
      those levels were significantly higher in the DMO group. Correlation analyses 
      revealed that IL-8 was positively and IFN-gamma was negatively correlated with the 
      severity of MO in the DMO group. In the BRVO-MO group, IL-8 and was positively 
      correlated with severity of MO and retinal ischaemia. CONCLUSIONS: DMO and 
      BRVO-MO may differ in terms of pathogenesis because the cytokine concentrations 
      in the aqueous humour differ. The results suggest that the inflammatory reaction 
      may be more activated in DMO than in BRVO-MO, and ischaemic insult may play a 
      central role in the development of BRVO-MO.
FAU - Lee, Won June
AU  - Lee WJ
AD  - Department of Ophthalmology, Hanyang University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kang, Min Ho
AU  - Kang MH
FAU - Seong, Mincheol
AU  - Seong M
FAU - Cho, Hee Yoon
AU  - Cho HY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120828
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Aqueous Humor/*chemistry
MH  - Biomarkers/metabolism
MH  - Cytokines/*metabolism
MH  - Diabetic Retinopathy/complications/*metabolism
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Macular Edema/etiology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Vein Occlusion/complications/*metabolism
EDAT- 2012/08/30 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - bjophthalmol-2012-301913 [pii]
AID - 10.1136/bjophthalmol-2012-301913 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2012 Nov;96(11):1426-30. doi: 10.1136/bjophthalmol-2012-301913. 
      Epub 2012 Aug 28.