PMID- 2293084
OWN - NLM
STAT- MEDLINE
DCOM- 19910409
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 120
IP  - 1
DP  - 1990 Nov 27
TI  - Evidence for a role of neosynthetized putrescine in the increase of glial 
      fibrillary acidic protein immunoreactivity induced by a mechanical lesion in the 
      rat brain.
PG  - 13-6
AB  - The effect of alpha-difluoromethylornithine (alpha-DFMO), an irreversible 
      inhibitor of ornithine decarboxylase (ODC) the rate limiting enzyme of polyamine 
      biosynthesis, was studied on the astroglial reaction in a model of mechanical 
      brain injury. alpha-DFMO markedly decreased the astroglial activation induced by 
      the microdialysis probe implantation in the striatum of the male rat, as studied 
      by glial fibrillary acidic protein (GFAP) immunocytochemistry. This response was 
      restored by putrescine (20 nmol/ml) administered via the microdialysis probe. 
      These results suggest that the astroglial reaction and the polyamine biosynthesis 
      activation induced by a localized mechanical lesion are causally linked 
      phenomena.
FAU - Zini, I
AU  - Zini I
AD  - Institute of Human Physiology, University of Modena, Italy.
FAU - Zoli, M
AU  - Zoli M
FAU - Grimaldi, R
AU  - Grimaldi R
FAU - Pich, E M
AU  - Pich EM
FAU - Biagini, G
AU  - Biagini G
FAU - Fuxe, K
AU  - Fuxe K
FAU - Agnati, L F
AU  - Agnati LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - V10TVZ52E4 (Putrescine)
RN  - ZQN1G5V6SR (Eflornithine)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects/*metabolism
MH  - Brain Injuries/*metabolism
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Eflornithine/*pharmacology
MH  - Glial Fibrillary Acidic Protein/analysis/*biosynthesis
MH  - Male
MH  - Putrescine/*biosynthesis/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1990/11/27 00:00
MHDA- 1990/11/27 00:01
CRDT- 1990/11/27 00:00
PHST- 1990/11/27 00:00 [pubmed]
PHST- 1990/11/27 00:01 [medline]
PHST- 1990/11/27 00:00 [entrez]
AID - 0304-3940(90)90156-4 [pii]
AID - 10.1016/0304-3940(90)90156-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 1990 Nov 27;120(1):13-6. doi: 10.1016/0304-3940(90)90156-4.