PMID- 22931040
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20120830
IS  - 0031-2983 (Print)
IS  - 0031-2983 (Linking)
VI  - 104
IP  - 3
DP  - 2012 Jun
TI  - Oncocytic papillary renal cell carcinoma: potential pitfall in small enucleation.
PG  - 98-100
AB  - OBJECTIVE: We describe an emerging entity, recently recognized as a pitfall in 
      the diagnostic practice among eosinophilic renal cell tumours. METHODS: A 
      60-year-old male underwent enucleation of a 1.2 cm nodule. Immunohistochemistry 
      and FISH analysis were performed. RESULTS: Histology revealed a neoplasm composed 
      of large cells with eosinophilic cytoplasm, Fuhrman grade 3, arranged in 
      papillae. At the immunohistochemical level, cells showed positivity for AMACR and 
      CD10. Fluorescence in situ hybridization (FISH) demonstrated gains of chromosomes 
      7 and 17 and loss of Y. A diagnosis of oncocytic papillary renal cell carcinoma 
      was made. CONCLUSIONS: The distinction between renal oncocytoma and oncocytic 
      papillary renal cell carcinoma is of substantial importance because of their 
      different behaviour and prognosis, since the latter has malignant potential. 
      Although the available evidence supporting tumour enucleation as the surgical 
      treatment for renal cortical tumours < or = 4 cm, due to aforementioned 
      clinicopathological features such tumours need to be evaluated using appropriate 
      immunophenotypical and cytogenetic analyses.
FAU - Munari, E
AU  - Munari E
AD  - Department of Pathology and Diagnostic, University of Verona, Italy. 
      enrico_munari@yahoo.it
FAU - Eccher, A
AU  - Eccher A
FAU - Segala, D
AU  - Segala D
FAU - Iannucci, A
AU  - Iannucci A
FAU - Gobbo, S
AU  - Gobbo S
FAU - Chilosi, M
AU  - Chilosi M
FAU - Brunelli, M
AU  - Brunelli M
FAU - Martignoni, G
AU  - Martignoni G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - Pathologica
JT  - Pathologica
JID - 0401123
SB  - IM
MH  - Adenoma, Oxyphilic/*diagnosis
MH  - Carcinoma, Renal Cell/classification/*pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Kidney/*pathology
MH  - Kidney Neoplasms/classification/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 2012/08/31 06:00
MHDA- 2012/09/18 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
PST - ppublish
SO  - Pathologica. 2012 Jun;104(3):98-100.