PMID- 22931704
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20221207
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 39
IP  - 5
DP  - 2012 Sep
TI  - The haplotype of the TGFbeta1 gene associated with cerebral infarction in Chinese.
PG  - 626-31
AB  - BACKGROUND: Transforming growth factor beta1 (TGFbeta1) is a multifunctional 
      cytokine involved in inflammation and pathogenesis of atherosclerosis. The aim of 
      the present study was to investigate the relationship between human TGFbeta1 gene 
      +869T>C (rs1800470), -509C>T (rs1800469) single nucleotide polymorphisms (SNPs) 
      and haplotypes and cerebral infarction (CI) in a Chinese population. METHODS: The 
      genetic association study was performed in 450 Chinese patients (306 male and 144 
      female) with CI and 450 control subjects (326 male and 124 female). TGFbeta1 gene 
      +869T>C and -509C>T polymorphisms were identified with amplification refractory 
      mutation system polymerase chain reaction and DNA sequencing method. RESULTS: The 
      individual SNPs analysis showed the +869T and -509C in an additive model (+869T 
      vs +869C; -509 C vs T), +869TT genotype in a recessive model (TT vs TC+CC) and 
      509CC genotype in a dominant model (CC+ CT vs TT) were identified to be related 
      to CI (P<0.05). +869T>C and -509C>T SNPs were in strong linkage disequilibrium 
      (d'=0.87, R2=0.75). Haplotype analysis showed that +869C/-509T haplotype was 
      associated with a significant decreased risk of CI (OR= 0.86, 95%CI, 0.70-0.92; 
      P=0.007). Furthermore,+869T/-509C haplotype was associated with a significant 
      increased risk of CI (OR=1.31, 95%CI, 1.10-2.03; P=0.019). CONCLUSIONS: The 
      results of this study indicate that polymorphisms and the haplotypes in the TGFbeta1 
      gene might be genetic markers for CI in the Chinese population.
FAU - Tao, Hong-miao
AU  - Tao HM
AD  - Jinhua College of Profession & Technology, Jinhua City.
FAU - Chen, Guo-zhong
AU  - Chen GZ
FAU - Cheng, Gan-ping
AU  - Cheng GP
FAU - Shan, Xiao-yun
AU  - Shan XY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
CIN - Can J Neurol Sci. 2012 Sep;39(5):568-9. PMID: 22931694
MH  - Aged
MH  - Asian People/genetics
MH  - Cerebral Infarction/*genetics
MH  - Confidence Intervals
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Haplotypes
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Retrospective Studies
MH  - Transforming Growth Factor beta1/*genetics
EDAT- 2012/08/31 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 4MR21503580127X2 [pii]
AID - 10.1017/s0317167100015365 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2012 Sep;39(5):626-31. doi: 10.1017/s0317167100015365.