PMID- 22931799
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20151119
IS  - 1001-0939 (Print)
IS  - 1001-0939 (Linking)
VI  - 35
IP  - 7
DP  - 2012 Jul
TI  - [Serum interleukin 18 and 33 levels and its clinical significance in asthma 
      patients].
PG  - 493-6
AB  - OBJECTIVE: To study the levels of serum interleukin (IL)-18 and IL-33 in 
      asthmatic patients pre-and post-treatment with glucocorticoids during the acute 
      exacerbation period and therefore to investigate the role of IL-18 and IL-33 in 
      the pathogenesis of bronchial asthma. METHODS: Thirty cases of moderate to severe 
      asthma admitted in the Second Affiliated Hospital of Dalian Medical University 
      from June, 2009 to October, 2010 were chosen as the asthma group, and 23 healthy 
      people who underwent routine physical examination were chosen as the control 
      group. The subjects in the 2 groups were all nonsmokers. All the patients were 
      treated with a glucocorticoid (methylprednisolone 40 - 80 mg/d) for 3 to 5 days 
      and combined with aerosol inhalation of budesonide for 1 to 2 weeks as adjuvant 
      therapy. The serum levels of IL-18 and IL-33 were detected for the asthma group 
      before and after the treatment and for the control group. Other data including 
      immunoglobulin E (IgE), the number of eosinophil cells (EOS) and the pulmonary 
      function (FEV(1)%pre) were measured as well. The differences of IL-18 and IL-33 
      levels between the asthma group before and after treatment and the control group 
      were analyzed, and the correlation between IL-18, IL-33 and IgE, EOS and 
      FEV(1)%pre were analyzed as well by SPSS software. RESULTS: Compared with the 
      healthy control group [(158 +/- 45) ng/L and (143 +/- 32) ng/L], the levels of IL-18 
      and IL-33 in the asthma pre-treatment group were significantly increased [(300 +/- 
      181) ng/L and (208 +/- 95) ng/L, t = 3.67 and 3.51, all P < 0.05)]; and the IgE 
      level and EOS count showed a similar change (t = 5.76 and 5.24, all P < 0.05). 
      After systemic glucocorticoid treatment and local aerosol inhalation, the levels 
      of IL-18 and IL-33 [(183 +/- 83) ng/L and (148 +/- 77) ng/L] were decreased 
      significantly in the asthma patients [t = 5.42 and 12.09, all P < 0.05], and the 
      IgE level and EOS count also showed a same trend as well (t = 11.87 and 4.56, all 
      P < 0.05), whereas FEV(1)%pred [(54 +/- 14)%] increased significantly [(81 +/- 16)%, 
      t = -7.81, P < 0.05]. The Pearson correlative analysis showed that there were 
      positive correlations between the levels of IL-18, IL-33 and IgE and EOS, 
      respectively (all P < 0.05), and there were negative correlations between IL-18, 
      IL-33 levels and FEV(1)%pre, respectively (all P < 0.05). CONCLUSIONS: Our 
      results suggest that IL-18 and IL-33 participate in the pathogenesis of asthma, 
      and may play stimulation role in the process of the disease.
FAU - Yang, Dong-xia
AU  - Yang DX
AD  - Department of Respiratory Disease, the Second Affiliated Hospital of Dalian 
      Medical University, Dalian 116000, China.
FAU - Li, Na
AU  - Li N
FAU - Zhang, Xiao-lin
AU  - Zhang XL
FAU - Wang, Qi
AU  - Wang Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Jie He He Hu Xi Za Zhi
JT  - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal 
      of tuberculosis and respiratory diseases
JID - 8712226
RN  - 0 (IL33 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-33)
RN  - 0 (Interleukins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asthma/*blood/drug therapy
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Interleukin-33
MH  - Interleukins/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2012/08/31 06:00
MHDA- 2015/03/31 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PST - ppublish
SO  - Zhonghua Jie He He Hu Xi Za Zhi. 2012 Jul;35(7):493-6.