PMID- 22932179
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220330
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 17
DP  - 2012 Sep
TI  - Relationship between 6-minute walk test and pulmonary function test in stable 
      chronic obstructive pulmonary disease with different severities.
PG  - 3053-8
AB  - BACKGROUND: The relationship between the 6-minute walk test (6MWT) and pulmonary 
      function test in stable chronic obstructive pulmonary disease (COPD) remains 
      unclear. We evaluate the correlation of 6MWT and spirometric parameters in stable 
      COPD with different severities. 6MWT data assessed included three variables: the 
      6-minute walk distance (6MWD), 6-minute walk work (6MWORK), and pulse oxygen 
      desaturation rate (SPO(2)%). METHODS: 6MWT and pulmonary function test were 
      assessed for 150 stable COPD patients with different severities. Means and 
      standard deviations were calculated for the variables of interest. Analysis of 
      variance was performed to compare means. Correlation coefficients were calculated 
      for 6MWT data with the spirometric parameters and dyspnea Borg scale. Multiple 
      stepwise regression analysis was used to screen pulmonary function-related 
      predictors of 6MWT data. RESULTS: The three variables of 6MWT all varied as the 
      severities of the disease. The 6MWD and 6MWORK both correlated with some 
      spirometric parameters (positive or negative correlation; the absolute value of r 
      ranging from 0.34 to 0.67; P < 0.05) in severe and very severe patients, and the 
      SPO2% correlated with the dyspnea Borg scale in four severities (r = -0.33, 
      -0.34, -0.39, -0.53 respectively; P < 0.05). The 6MWD was correlated with the 
      6MWORK in four severities (r = 0.56, 0.57, 0.72, 0.81 respectively, P < 0.05), 
      and neither of them correlated with the SPO(2)%. The percent of predicted forced 
      expiratory volume in 1 second (FEV(1)% predicted) and residual volume to total 
      lung capacity ratio (RV/TLC) were predictors of the 6MWD, and the maximum 
      voluntary ventilation (MVV) was the predictor of the 6MWORK. CONCLUSIONS: 6MWT 
      correlated with the spirometric parameters in severe and very severe COPD 
      patients. 6MWT may be used to monitor changes of pulmonary function in these 
      patients.
FAU - Chen, Hong
AU  - Chen H
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China.
FAU - Liang, Bin-Miao
AU  - Liang BM
FAU - Tang, Yong-Jiang
AU  - Tang YJ
FAU - Xu, Zhi-Bo
AU  - Xu ZB
FAU - Wang, Ke
AU  - Wang K
FAU - Yi, Qun
AU  - Yi Q
FAU - Ou, Xue-Mei
AU  - Ou XM
FAU - Feng, Yu-Lin
AU  - Feng YL
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology
MH  - Regression Analysis
MH  - Respiratory Function Tests
MH  - Walking/*physiology
EDAT- 2012/08/31 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Sep;125(17):3053-8.