PMID- 22932891
OWN - NLM
STAT- MEDLINE
DCOM- 20130514
LR  - 20181202
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 150
IP  - 1-3
DP  - 2012 Dec
TI  - Zinc suppressed the airway inflammation in asthmatic rats: effects of zinc on 
      generation of eotaxin, MCP-1, IL-8, IL-4, and IFN-gamma.
PG  - 314-21
LID - 10.1007/s12011-012-9493-7 [doi]
AB  - Airway epithelium is rich in labile zinc (Zn), which may have an important 
      protective role in the airway epithelium. The aim of this study is to investigate 
      the effects of Zn on the airway inflammation and the generation of eotaxin, 
      monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), interleukin-4 
      (IL-4), and interferon-gamma (IFN-gamma) in rat models of ovalbumin (OVA)-induced 
      allergic airway inflammation. For this purpose, animal model of asthma was 
      established by OVA challenge and zinc-deficient and zinc-supplemented diets were 
      given. Thirty-two Sprague-Dawley rats were divided into four groups: 
      zinc-deficient diet with OVA treatment group, zinc-supplemented diet with OVA 
      treatment group, zinc-normal diet with OVA treatment group, and zinc-normal diet 
      with saline treatment group. Twenty-four hours after asthma was induced, lung 
      histomorphological changes, cells in bronchoalveolar lavage fluid (BALF), 
      contents of eotaxin, MCP-1, and IL-8 in BALF, and the expression of IFN-gamma and 
      IL-4 mRNAs were observed. Compared with the group of zinc-normal diet with OVA 
      challenge rats, the group of zinc-deficient rats had higher numbers of 
      eosinophils, neutrophils, and monocytes in BALF, as well as higher contents of 
      eotaxin and MCP-1 in BALF and lower expression of lung IFN-gamma mRNA. Conversely, Zn 
      supplementation would decrease the numbers of eosinophils, neutrophils, and 
      monocytes in BALF; suppress eotaxin and MCP-1 protein secretion; and increase 
      lung IFN-gamma mRNA expression. No significant difference was observed in IL-8 and 
      IL-4 among OVA-challenged rats with different zinc diets. These studies suggested 
      that Zn may be an important anti-inflammatory mediator of airway inflammation.
FAU - Lu, Hongyan
AU  - Lu H
AD  - Department of Pediatrics, The Affiliated Hospital of Jiangsu University, 
      Zhenjiang, 212001, China. lhy5154@163.com
FAU - Xin, Yue
AU  - Xin Y
FAU - Tang, Yan
AU  - Tang Y
FAU - Shao, Genbao
AU  - Shao G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120830
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cytokines)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Asthma/*diet therapy/etiology/immunology/metabolism
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology/immunology
MH  - Cell Count
MH  - Cytokines/antagonists & inhibitors/genetics/metabolism
MH  - *Dietary Supplements
MH  - Eosinophils/immunology/metabolism
MH  - Gene Expression Regulation
MH  - Lung/cytology/*immunology/metabolism
MH  - Male
MH  - Monocytes/immunology/metabolism
MH  - Neutrophil Infiltration
MH  - Neutrophils/immunology/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Respiratory Mucosa/cytology/*immunology/metabolism
MH  - Spectrophotometry, Atomic
MH  - Zinc/blood/deficiency/*therapeutic use
EDAT- 2012/08/31 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/05/18 00:00 [received]
PHST- 2012/08/08 00:00 [accepted]
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - 10.1007/s12011-012-9493-7 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2012 Dec;150(1-3):314-21. doi: 10.1007/s12011-012-9493-7. 
      Epub 2012 Aug 30.