PMID- 22934098
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120830
LR  - 20220129
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Stromal cell induction of regulatory dendritic cells.
PG  - 262
LID - 10.3389/fimmu.2012.00262 [doi]
LID - 262
AB  - Dendritic cells (DCs) are specialized antigen presenting cells of bone marrow 
      origin that can exist in tissues in either an immature or mature state. DCs have 
      a myriad of roles in immunity and tolerance induction, but are perhaps best known 
      for their role in the activation and differentiation of naive T cells at the 
      onset of an acquired immune response. Over the past decade, a body of literature 
      has developed that suggests that DCs, as well as many other myeloid cell 
      populations, are also capable of exerting "regulatory" effects on T cell 
      responses. However, relatively little is known regarding the mechanisms by which 
      such regulatory myeloid cells arise in vivo. In this mini-review, we first define 
      the characteristics of "regulatory" DCs (rDCs) and then focus on the contribution 
      of non-hematopoietic stromal cells to their generation within specific tissue 
      microenvironments. We also highlight areas of research that warrant future 
      attention, arguing for a focusing of efforts toward a better understanding of the 
      features of stromal cell populations that enable the induction of rDCs. Finally, 
      we discuss how an understanding of stromal cell-myeloid cell interactions may 
      lead to new therapeutic strategies for cancer, autoimmunity, and infectious 
      disease.
FAU - Owens, Benjamin M J
AU  - Owens BM
AD  - Centre for Immunology and Infection, Hull York Medical School and Department of 
      Biology, University of York York, UK.
FAU - Kaye, Paul M
AU  - Kaye PM
LA  - eng
GR  - G0400786/MRC_/Medical Research Council/United Kingdom
GR  - G1000230/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20120821
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3423630
OTO - NOTNLM
OT  - IL-10
OT  - Immune regulation
OT  - dendritic cells
OT  - infection
OT  - inflammation
OT  - stromal cells
EDAT- 2012/08/31 06:00
MHDA- 2012/08/31 06:01
PMCR- 2012/01/01
CRDT- 2012/08/31 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/08/31 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00262 [doi]
PST - epublish
SO  - Front Immunol. 2012 Aug 21;3:262. doi: 10.3389/fimmu.2012.00262. eCollection 
      2012.