PMID- 22934390
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20161020
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 37
IP  - 3
DP  - 2012 Jun
TI  - [Effects of different quantity of moxibustion at "Dazhui" (GV 14) on cellular 
      immunity in asthma rats].
PG  - 202-5, 217
AB  - OBJECTIVE: To observe the effects of different quantity of moxibustion of 
      "Dazhui" (GV 14)on the levels of serum interleukin-4 (IL-4), interferon-gamma 
      (IFN-gamma), and immunoglobulin E (IgE) in asthma rats, so as to reveal its 
      mechanisms underlying immune regulation. METHODS: Sixty male SD rats were 
      randomly divided into control, model, moxibustion-15 min (M-15 min), M-30 min, 
      M-60 min, and M-120 min groups (10 rats/group). Asthma model was established by 
      intraperitoneal injection of sensitized-suspension (containing egg albumin, 
      aluminium hydroxide, and deactivated Bacillus pertussis) and ovalbumin-aerosol 
      inhalation. Moxibustion was applied to "Dazhui" (GV 14) for 15, 30, 60 and 120 
      min, respectively. Serum IL-4, IFN-gamma and IgE contents were assayed by ELISA 
      (enzyme-linked immunosorbent assay). RESULTS: Compared with the control group, 
      serum IL-4, IFN-gamma and IgE levels were increased significantly (P<0.01), and 
      serum IFN-gamma/IL-4 level was down-regulated obviously (P<0.01)in the model 
      group. After the moxibustion treatment, the levels of serum IL-4 and IgE in the 
      M-15 min, M-30 min, M-60 min, and M-120 min groups were reduced significantly 
      compared with the model group (P<0.01, P<0.05). The ratios of IFN-gamma/IL-4 in 
      the M-15 min, M-30 min, M-60 min, and M-120 min groups were significantly higher 
      than that in the model group (P<0.05, P<0.01). Comparison among the M-15 min, 
      M-30 min, M-60 min, and M-120 min groups showed that the therapeutic effects of 
      the M-30 min group were evidently superior to those of the M-15 min group, and 
      those of the M-60 min group were significantly superior to those of the M-30 min 
      group in lowering serum IL-4 and IgE contents and up-regulating IFN-gamma/IL-4 
      (P<0.05, P<0.01). No significant differences were found between the M-60 min and 
      M-120 min groups in down-regulating IL-4 and IgE levels, and in raising 
      IFN-gamma/IL-4 level, as well as among the M-15min, M-30 min, M-60 min and M-120 
      min groups in elevating serum IFN-gamma levels (P>0.05). CONCLUSION: Moxibustion 
      can restrain the secretion of IL-4, relieve the inflammatory reaction of IgE, and 
      enhance the ratio of IFN-gamma/IL-4 in asthma rats, which presents an increase 
      tendency of the curative effect along with the extension of the treatment time 
      from 15 min to 60 min. Excessively long time (>60 min)of treatment is not 
      necessary.
FAU - Zhang, Wei
AU  - Zhang W
AD  - The Affiliated Hospital of Jiangxi College of Chinese Medicine, Nanchang 330006, 
      China.
FAU - Chen, Ming-Ren
AU  - Chen MR
FAU - Xiong, Jun
AU  - Xiong J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - *Acupuncture Points
MH  - Animals
MH  - Asthma/blood/*immunology/*therapy
MH  - *Immunity, Cellular
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/blood
MH  - Interleukin-4/blood
MH  - Male
MH  - *Moxibustion
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/09/01 06:00
MHDA- 2012/10/13 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2012 Jun;37(3):202-5, 217.