PMID- 22935565
OWN - NLM
STAT- MEDLINE
DCOM- 20130514
LR  - 20161125
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 45
IP  - 18
DP  - 2012 Dec
TI  - Urinary ketone is associated with the heart failure severity.
PG  - 1697-9
LID - S0009-9120(12)00493-6 [pii]
LID - 10.1016/j.clinbiochem.2012.08.013 [doi]
AB  - OBJECTIVES: To test the hypothesis that urinary metabolites characterizing heart 
      failure (HF) are associated with the magnitude of echocardiographic measurements 
      and ultimately the severity of HF. DESIGN/METHODS: Patients with systolic HF 
      (n=46) and control subjects (n=32) participated in this study. Patients with type 
      2 diabetes mellitus were excluded. Echocardiographic measurements were performed, 
      and selected urinary metabolites were quantified. RESULTS: Urinary levels of 
      acetate (p<0.05), acetone (p<0.01), cytosine (p<0.001), methylmalonate (p<0.001), 
      and phenylacetylglycine (p<0.01) were significantly higher, while 
      1-methylnicotinamide (p<0.05) were significantly lower in HF patients than in 
      controls. There were significant differences in E/E' (p<0.05), urinary levels of 
      acetate (p<0.005), acetoacetate (p<0.05), acetone (p<0.05) and ketones (p<0.01) 
      according to the New York Heart Association (NYHA) classification in HF patients. 
      Multiple linear regression analysis revealed that urinary ketones were found to 
      be independent factors for both left ventricular ejection fraction and E/E' after 
      adjusting for confounders. CONCLUSION: Our results showed that urinary levels of 
      ketone bodies are associated with the magnitude of echocardiographic parameters.
CI  - Copyright (c) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Chung, Ji Hyung
AU  - Chung JH
AD  - Cardiovascular Product Evaluation Center, Cardiovascular Research Institute, 
      Yonsei University Health System, Seoul, Republic of Korea.
FAU - Kim, Jin-Sup
AU  - Kim JS
FAU - Kim, Oh Yoen
AU  - Kim OY
FAU - Kang, Seok-Min
AU  - Kang SM
FAU - Hwang, Geum-Sook
AU  - Hwang GS
FAU - Shin, Min-Jeong
AU  - Shin MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120824
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Ketones)
SB  - IM
MH  - Aged
MH  - Female
MH  - Heart Failure/classification/diagnostic imaging/*pathology/*urine
MH  - Humans
MH  - Ketones/*urine
MH  - Male
MH  - New York
MH  - Regression Analysis
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Ultrasonography
EDAT- 2012/09/01 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/08/06 00:00 [revised]
PHST- 2012/08/11 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - S0009-9120(12)00493-6 [pii]
AID - 10.1016/j.clinbiochem.2012.08.013 [doi]
PST - ppublish
SO  - Clin Biochem. 2012 Dec;45(18):1697-9. doi: 10.1016/j.clinbiochem.2012.08.013. 
      Epub 2012 Aug 24.