PMID- 22936020
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220317
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 23
IP  - 7
DP  - 2012 Nov
TI  - Predictive value of red cell distribution width in intrahospital mortality and 
      postintervention thrombolysis in myocardial infarction flow in patients with 
      acute anterior myocardial infarction.
PG  - 450-4
AB  - OBJECTIVES: Recent studies have reported a strong independent association between 
      increased red cell distribution width (RDW) and the risk of adverse outcomes in 
      patients with heart failure, stable coronary disease, and acute coronary 
      syndromes. However, in this study we aimed to determine the impact of an elevated 
      RDW level on the postinterventional thrombolysis in myocardial infarction (TIMI) 
      flow and intrahospital mortality in patients with acute anterior myocardial 
      infarction (AMI). METHODS: A total of 763 patients with acute AMI undergoing a 
      primary percutaneous coronary intervention were evaluated retrospectively. Upon 
      admission, the RDW level was measured by an automated complete blood count. 
      Postinterventional TIMI flow and intrahospital mortality was documented for all 
      patients from hospital registries. The patients were classified according to the 
      RDW level. RDW more than 14.8% was defined as elevated RDW. All groups were 
      compared statistically according to the preinterventional characteristics. 
      RESULTS: Elevated RDW was found to be an independent predictor of increased 
      intrahospital mortality in multivariate regression analysis (hazard ratio: 3.677, 
      95% confidence interval: 1.228-11.008, P=0.02). Other independent predictors for 
      intrahospital mortality were diabetes mellitus (hazard ratio: 6.743, 95% 
      confidence interval: 1.941-23.420, P=0.003), smoking (hazard ratio: 6.779, 95% 
      confidence interval: 1.505-30.534, P=0.013), and creatinine more than 0.8 mg/dl 
      (hazard ratio: 7.982, 95% confidence interval: 1.759-36.211, P=0.007). However, 
      there were no independent predictors for TIMI including elevated RDW. CONCLUSION: 
      A high admission RDW level in patients with acute AMI undergoing a primary 
      percutaneous coronary intervention was associated with an increased risk for 
      intrahospital cardiovascular mortality, but was not associated with worse 
      postinterventional TIMI flow.
CI  - (c) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
FAU - Ilhan, Erkan
AU  - Ilhan E
AD  - Department of Cardiology, Van Ercis State Hospital, Van, Turkey. 
      erkan.ilhan@yahoo.com.tr
FAU - Guvenc, Tolga S
AU  - Guvenc TS
FAU - Altay, Servet
AU  - Altay S
FAU - Cagdas, Metin
AU  - Cagdas M
FAU - Calik, Ali N
AU  - Calik AN
FAU - Karaca, Mehmet
AU  - Karaca M
FAU - Guzelburc, Ozge
AU  - Guzelburc O
FAU - Karaca, Gurkan
AU  - Karaca G
FAU - Biteker, Murat
AU  - Biteker M
FAU - Tayyareci, Gulsah
AU  - Tayyareci G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
SB  - IM
EIN - Coron Artery Dis. 2021 Dec 1;32(8):744. PMID: 34817464
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anterior Wall Myocardial 
      Infarction/blood/diagnosis/*mortality/physiopathology/*therapy
MH  - Chi-Square Distribution
MH  - *Coronary Circulation
MH  - *Erythrocyte Indices
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Patient Admission
MH  - Percutaneous Coronary Intervention/adverse effects/*mortality
MH  - Predictive Value of Tests
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/09/01 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - 10.1097/MCA.0b013e3283587897 [doi]
PST - ppublish
SO  - Coron Artery Dis. 2012 Nov;23(7):450-4. doi: 10.1097/MCA.0b013e3283587897.