PMID- 22936316
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20220419
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 142
DP  - 2012
TI  - HLA and non-HLA polymorphisms in renal transplantation.
PG  - w13668
LID - 10.4414/smw.2012.13668 [doi]
AB  - Despite progress made in the field of immunosuppression, graft rejection remains 
      a major cause of morbidity and mortality of patients after solid organ 
      transplantation. There are several genetic causes which could influence the 
      outcome of renal transplantation. One of the main determining factors of success 
      in renal transplantation is human leukocyte antigen (HLA) compatibility between 
      donor and recipient, particularly at HLA-A, HLA-B and HLA-DR loci. HLA 
      compatibility remains an essential immunological barrier, despite modern 
      immunosuppressive treatments. There is also evidence that natural killer (NK) 
      cell alloreactivity contributes to the immune response which modulates the 
      outcome of renal transplantation. However, the clinical impact of combinations of 
      KIR genes (family of NK cell receptors) and their HLA ligands in donor and 
      recipient still remains to be clearly established. Furthermore, cytokines are 
      involved in the immune reaction against the renal transplant, but the implication 
      of the genetic polymorphism of cytokines is strongly debated. Therefore, while 
      HLA compatibility remains a primordial component for any renal transplantation, 
      it would be premature to use the two other genetic aspects as criteria for organ 
      allocation and as prognostic factors.
FAU - Laperrousaz, Stephanie
AU  - Laperrousaz S
AD  - Transplant Immunology Unit and Swiss National Reference Laboratory for 
      Histocompatibility (LNRH), Geneva University Hospital and Medical School, Geneva, 
      Switzerland. sylvie.ferrari[at]hcuge.ch
FAU - Tiercy, Stephanie
AU  - Tiercy S
FAU - Villard, Jean
AU  - Villard J
FAU - Ferrari-Lacraz, Sylvie
AU  - Ferrari-Lacraz S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120830
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
RN  - 0 (Cytokines)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Cytokines/genetics/immunology
MH  - Genetic Markers
MH  - Graft Rejection/*genetics/immunology/prevention & control
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Killer Cells, Natural/immunology
MH  - *Polymorphism, Genetic
MH  - Receptors, KIR/genetics/immunology
EDAT- 2012/09/01 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - smw-13668 [pii]
AID - 10.4414/smw.2012.13668 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2012 Aug 30;142:w13668. doi: 10.4414/smw.2012.13668. eCollection 
      2012.