PMID- 22936723
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20130926
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 113
IP  - 8
DP  - 2012 Oct 15
TI  - Voluntary resistance running with short distance enhances spatial memory related 
      to hippocampal BDNF signaling.
PG  - 1260-6
LID - 10.1152/japplphysiol.00869.2012 [doi]
AB  - Although voluntary running has beneficial effects on hippocampal cognitive 
      functions if done abundantly, it is still uncertain whether resistance running 
      would be the same. For this purpose, voluntary resistance wheel running (RWR) 
      with a load is a suitable model, since it allows increased work levels and 
      resultant muscular adaptation in fast-twitch muscle. Here, we examined whether 
      RWR would have potential effects on hippocampal cognitive functions with enhanced 
      hippocampal brain-derived neurotrophic factor (BDNF), as does wheel running 
      without a load (WR). Ten-week-old male Wistar rats were assigned randomly to 
      sedentary (Sed), WR, and RWR (to a maximum load of 30% of body weight) groups for 
      4 wk. We found that in RWR, work levels increased with load, but running distance 
      decreased by about half, which elicited muscular adaptation for fast-twitch 
      plantaris muscle without causing any negative stress effects. Both RWR and WR led 
      to improved spatial learning and memory as well as gene expressions of 
      hippocampal BDNF signaling-related molecules. RWR increased hippocampal BDNF, 
      tyrosine-related kinase B (TrkB), and cAMP response element-binding (CREB) 
      protein levels, whereas WR increased only BDNF. With both exercise groups, there 
      were correlations between spatial memory and BDNF protein (r = 0.41), p-CREB 
      protein (r = 0.44), and work levels (r = 0.77). These results suggest that RWR 
      plays a beneficial role in hippocampus-related cognitive functions associated 
      with hippocampal BDNF signaling, even with short distances, and that work levels 
      rather than running distance are more determinant of exercise-induced beneficial 
      effects in wheel running with and without a load.
FAU - Lee, Min Chul
AU  - Lee MC
AD  - Laboratory of Exercise Biochemistry and Neuroendocrinology, Institute for Health 
      and Sports Science, University of Tsukuba, Tsukuba, Japan.
FAU - Okamoto, Masahiro
AU  - Okamoto M
FAU - Liu, Yu Fan
AU  - Liu YF
FAU - Inoue, Koshiro
AU  - Inoue K
FAU - Matsui, Takashi
AU  - Matsui T
FAU - Nogami, Haruo
AU  - Nogami H
FAU - Soya, Hideaki
AU  - Soya H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120830
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/physiology
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Hippocampus/metabolism/*physiology
MH  - Learning/physiology
MH  - Male
MH  - Memory/*physiology
MH  - Muscle Fibers, Fast-Twitch/metabolism/physiology
MH  - Muscle, Skeletal/metabolism/physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/metabolism
MH  - Running/*physiology
MH  - Signal Transduction
MH  - Stress, Psychological/metabolism/prevention & control
EDAT- 2012/09/01 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - japplphysiol.00869.2012 [pii]
AID - 10.1152/japplphysiol.00869.2012 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2012 Oct 15;113(8):1260-6. doi: 
      10.1152/japplphysiol.00869.2012. Epub 2012 Aug 30.