PMID- 22937525
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120831
LR  - 20220409
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 2
DP  - 2012
TI  - Effects of ionizing radiation on the immune system with special emphasis on the 
      interaction of dendritic and T cells.
PG  - 102
LID - 10.3389/fonc.2012.00102 [doi]
LID - 102
AB  - Dendritic cells (DCs), as professional antigen-presenting cells, are members of 
      the innate immune system and function as key players during the induction phase 
      of adaptive immune responses. Uptake, processing, and presentation of antigens 
      direct the outcome toward either tolerance or immunity. The cells of the immune 
      system are among the most highly radiosensitive cells in the body. For high doses 
      of ionizing radiation (HD-IR) both immune-suppressive effects after whole body 
      irradiation and possible immune activation during tumor therapy were observed. On 
      the other hand, the effects of low doses of ionizing radiation (LD-IR) on the 
      immune system are controversial and seem to show high variability among different 
      individuals and species. There are reports revealing that protracted LD-IR can 
      result in radioresistance. But immune-suppressive effects of chronic LD-IR are 
      also reported, including the killing or sensitizing of certain cell types. This 
      article shall review the current knowledge of radiation-induced effects on the 
      immune system, paying special attention to the interaction of DCs and T cells.
FAU - Manda, Katrin
AU  - Manda K
AD  - Department of Radiotherapy and Radiation Oncology, University of Rostock Rostock, 
      Germany.
FAU - Glasow, Annegret
AU  - Glasow A
FAU - Paape, Daniel
AU  - Paape D
FAU - Hildebrandt, Guido
AU  - Hildebrandt G
LA  - eng
PT  - Journal Article
DEP - 20120824
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC3426842
OTO - NOTNLM
OT  - T cells
OT  - dendritic cells
OT  - immune system
OT  - ionizing radiation
OT  - low dose
EDAT- 2012/09/01 06:00
MHDA- 2012/09/01 06:01
PMCR- 2012/01/01
CRDT- 2012/09/01 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2012/09/01 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2012.00102 [doi]
PST - epublish
SO  - Front Oncol. 2012 Aug 24;2:102. doi: 10.3389/fonc.2012.00102. eCollection 2012.