PMID- 22937846
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20120903
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 33
IP  - 3
DP  - 2012 Sep
TI  - Do cystic vestibular schwannomas have worse surgical outcomes? Systematic 
      analysis of the literature.
PG  - E12
LID - 10.3171/2012.6.FOCUS12200 [doi]
AB  - OBJECT: The goal of this study was to perform a systematic quantitative 
      comparison of the surgical outcomes between cystic vestibular schwannomas (CVSs) 
      and solid vestibular schwannomas (SVSs). METHODS: A review of English-language 
      literature published between 1990 and 2011 was performed using various search 
      engines including PubMed, Google Scholar, and the Cochrane database. Only studies 
      that reported surgical results of CVSs in comparison with SVSs were included in 
      the analysis. The primary end point of this study was surgical outcomes, defined 
      by the following: 1) facial nerve outcomes at latest follow-up; 2) mortality 
      rates; or 3) non-facial nerve complication index. Secondary end points included 
      extent of resection and brainstem adherence. RESULTS: Nine studies comprising 428 
      CVSs and 1287 SVSs were included in the study. The mean age of patients 
      undergoing surgery was 48.3 +/- 6.75 and 47.1 +/- 9 years for CVSs and SVSs, 
      respectively (p = 0.8). The mean tumor diameter for CVSs was 3.9 +/- 0.84 cm and 
      that for SVSs was 3.7 +/- 1.2 cm (p = 0.7). There was no significant difference in 
      the extent of resection among CVSs and SVSs (81.2% vs 80.7%, p = 0.87) Facial 
      nerve outcomes were significantly better in the cohort of patients with SVSs than 
      in those with CVSs (52.1% vs 39%, p = 0.0001). The perioperative mortality rates 
      for CVSs and SVSs were not significantly different (3% and 3.8%, respectively; p 
      = 0.6). No significant difference was noted between the cumulative non-facial 
      nerve complication rate (including mortality) among patients with CVSs and SVSs 
      (24.5% and 25.6%, respectively; p = 0.75) CONCLUSIONS: Facial nerve outcomes are 
      worse in patients undergoing resection for CVSs than in patients undergoing 
      resection for SVSs. There were no significant differences in the extent of 
      resection or postoperative morbidity and mortality rates between the cohorts of 
      patients with vestibular schwannomas.
FAU - Thakur, Jai Deep
AU  - Thakur JD
AD  - Department of Neurosurgery, Louisiana State University Health Sciences Center 
      Shreveport, Louisiana 71103, USA.
FAU - Khan, Imad Saeed
AU  - Khan IS
FAU - Shorter, Cedric D
AU  - Shorter CD
FAU - Sonig, Ashish
AU  - Sonig A
FAU - Gardner, Gale L
AU  - Gardner GL
FAU - Guthikonda, Bharat
AU  - Guthikonda B
FAU - Nanda, Anil
AU  - Nanda A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
MH  - Central Nervous System Cysts/complications/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuroma, Acoustic/complications/*surgery
MH  - Neurosurgical Procedures/*adverse effects
MH  - *Postoperative Complications
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2012/09/04 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.3171/2012.6.FOCUS12200 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2012 Sep;33(3):E12. doi: 10.3171/2012.6.FOCUS12200.