PMID- 22939575
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20121211
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 44
IP  - 1
DP  - 2013 Jan
TI  - Juxtaglomerular cell tumor: a morphological, immunohistochemical and genetic 
      study of six cases.
PG  - 47-54
LID - S0046-8177(12)00143-8 [pii]
LID - 10.1016/j.humpath.2012.04.006 [doi]
AB  - Juxtaglomerular cell tumors (JGCTs) are rare tumors characterized by renin 
      synthesis, hyperaldosteronism and hypertension. A curious immunohistochemical 
      overlap between JGCT and gastrointestinal stromal tumor (GIST) including the 
      expression of vimentin, CD34, CD117, alpha-smooth muscle actin was previously 
      reported, prompting us to further investigate JGCT and its phenotypic and 
      molecular genetic characteristics. Virtual karyotyping showed gain of chromosomes 
      3, 4, 10, 13, 17 and 18 in one JGCT, and fluorescence in situ hybridization 
      (FISH) study confirmed this multiple gain pattern. Additionally, loss of 
      chromosome 9 was observed in four of six cases analyzed with FISH. A whole genome 
      expression analysis revealed 415 up-regulated (including renin, and CD117) and 
      325 down-regulated genes between the 2 cases. The study confirmed earlier reports 
      on the gain of chromosomes 4 and 10, and provided further evidence of 
      up-regulation of the genes located on these 2 chromosomes. For the first time our 
      study indicated the importance of the loss of chromosome 9 and loss of expression 
      of several tumor suppressor genes located on this chromosome as possible 
      pathogenetic events important in development of JGCT.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Kuroda, Naoto
AU  - Kuroda N
AD  - Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, 
      Japan.
FAU - Maris, Sperga
AU  - Maris S
FAU - Monzon, Federico A
AU  - Monzon FA
FAU - Tan, Puay Hoon
AU  - Tan PH
FAU - Thomas, Anjula
AU  - Thomas A
FAU - Petersson, Fredrik B
AU  - Petersson FB
FAU - Gatalica, Zoran
AU  - Gatalica Z
FAU - Ghazalpour, Anatole
AU  - Ghazalpour A
FAU - Bender, Ryan P
AU  - Bender RP
FAU - Grossmann, Petr
AU  - Grossmann P
FAU - Michal, Michal
AU  - Michal M
FAU - Svajdler, Marian
AU  - Svajdler M
FAU - Ovcak, Zdenka
AU  - Ovcak Z
FAU - Hora, Milan
AU  - Hora M
FAU - Hes, Ondrej
AU  - Hes O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120829
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (beta Catenin)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Adult
MH  - Cytoplasmic Granules/genetics/pathology/ultrastructure
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Juxtaglomerular Apparatus/chemistry/metabolism/*pathology
MH  - Karyotyping
MH  - Male
MH  - Proto-Oncogene Proteins c-kit/chemistry/genetics/ultrastructure
MH  - Renin/chemistry/genetics/ultrastructure
MH  - Young Adult
MH  - beta Catenin/chemistry/genetics/ultrastructure
EDAT- 2012/09/04 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/02/09 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/04/11 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - S0046-8177(12)00143-8 [pii]
AID - 10.1016/j.humpath.2012.04.006 [doi]
PST - ppublish
SO  - Hum Pathol. 2013 Jan;44(1):47-54. doi: 10.1016/j.humpath.2012.04.006. Epub 2012 
      Aug 29.