PMID- 22942271
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1718-4304 (Electronic)
IS  - 0896-8608 (Print)
IS  - 0896-8608 (Linking)
VI  - 32
IP  - 5
DP  - 2012 Sep-Oct
TI  - Pulmonary congestion and physical functioning in peritoneal dialysis patients.
PG  - 531-6
AB  - PURPOSE: Decline in physical function is commonly observed in patients with 
      kidney failure on dialysis. Whether lung congestion, a predictable consequence of 
      cardiomyopathy and fluid overload, may contribute to the low physical functioning 
      of these patients has not been investigated. METHODS: In 51 peritoneal dialysis 
      (PD) patients, we investigated the cross-sectional association between the 
      physical functioning scale of the Kidney Disease Quality of Life Short Form 
      (KDQOL-SF: Rand Corporation, Santa Monica, CA, USA) and an ultrasonographic 
      measure of lung water recently validated in dialysis patients. The relationship 
      between physical functioning and lung water was also analyzed taking into account 
      the severity of dyspnea measured using the New York Heart Association (NYHA) 
      classification currently used to grade the severity of heart failure. RESULTS: 
      Evidence of moderate-to-severe lung congestion was evident in 20 patients, and 
      this alteration was asymptomatic (that is, NHYHA class I) in 11 patients (55%). 
      On univariate analysis, physical functioning was inversely associated with lung 
      water (r = -0.48, p < 0.001), age (r = -0.44, p = 0.001), previous cardiovascular 
      events (r = -0.46, p = 0.001), and fibrinogen (r = -0.34, p = 0.02). Physical 
      functioning was directly associated with blood pressure, the strongest 
      association being with diastolic blood pressure (r = 0.38, p = 0.006). The NYHA 
      class correlated inversely with physical functioning (r = -0.51, p < 0.001). In 
      multiple regression analysis, only lung water and fibrinogen remained independent 
      correlates of physical functioning. The NYHA class failed to maintain its 
      independent association. CONCLUSIONS: This cross-sectional study supports the 
      hypothesis that symptomatic and asymptomatic lung congestion is a relevant factor 
      in the poor physical functioning of patients on PD.
FAU - Enia, Giuseppe
AU  - Enia G
AD  - Nephrology, Dialysis, Hypertension and Renal Transplantation Unit, Azienda 
      Ospedaliera, Reggio Calabria, Italy. enia1951@gmail.com
FAU - Tripepi, Rocco
AU  - Tripepi R
FAU - Panuccio, Vincenzo
AU  - Panuccio V
FAU - Torino, Claudia
AU  - Torino C
FAU - Garozzo, Maurizio
AU  - Garozzo M
FAU - Battaglia, Giovanni Giorgio
AU  - Battaglia GG
FAU - Zoccali, Carmine
AU  - Zoccali C
LA  - eng
PT  - Journal Article
DEP - 20120901
PL  - United States
TA  - Perit Dial Int
JT  - Peritoneal dialysis international : journal of the International Society for 
      Peritoneal Dialysis
JID - 8904033
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Cross-Sectional Studies
MH  - Dyspnea/*diagnosis
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*physiopathology/therapy
MH  - Male
MH  - Motor Activity
MH  - Peritoneal Dialysis/*adverse effects
MH  - Pulmonary Edema/diagnostic imaging/*etiology
MH  - *Quality of Life
MH  - Regression Analysis
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC3524861
EDAT- 2012/09/04 06:00
MHDA- 2013/03/15 06:00
PMCR- 2013/09/01
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - pdi.2010.00250 [pii]
AID - 10.3747/pdi.2010.00250 [doi]
PST - ppublish
SO  - Perit Dial Int. 2012 Sep-Oct;32(5):531-6. doi: 10.3747/pdi.2010.00250. Epub 2012 
      Sep 1.