PMID- 22943397
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140828
LR  - 20120904
IS  - 1744-8336 (Electronic)
IS  - 1478-7210 (Linking)
VI  - 10
IP  - 7
DP  - 2012 Jul
TI  - Immune reconstitution inflammatory syndrome in a large multicenter cohort study: 
      case definition and comparability.
PG  - 737-41
LID - 10.1586/eri.12.62 [doi]
AB  - This study was nested within the HIV Outpatient Study cohort and investigated the 
      incidence and risk factors for immune reconstitution inflammatory syndrome (IRIS) 
      and the impact of IRIS on mortality. IRIS was defined as a new type B or C 
      AIDS-defining condition or one of a range of mucocutaneous or autoimmune 
      conditions diagnosed within 180 days of starting a new combination antiretroviral 
      therapy regimen, provided there was a documented HIV viral load or CD4 response. 
      IRIS occurred in 10.6% of the 2610 patients. Risk factors independently 
      associated with IRIS included high HIV viral load and low CD4 count. IRIS related 
      to type B or C AIDS-defining conditions was associated with subsequent mortality. 
      Deaths among IRIS cases occurred over 3 years (median) after the IRIS event, 
      making it unlikely that these deaths were directly attributable to IRIS. The IRIS 
      case definition used has important differences when compared with previously 
      published IRIS case definitions thereby affecting comparability of these 
      findings, but this was a pragmatic definition for a large multicenter cohort 
      study utilizing a central database.
FAU - Meintjes, Graeme
AU  - Meintjes G
AD  - Clinical Infectious Diseases Research Initiative, Institute of Infectious 
      Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western 
      Cape, South Africa. graemein@mweb.co.za
FAU - Boulle, Andrew
AU  - Boulle A
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Expert Rev Anti Infect Ther
JT  - Expert review of anti-infective therapy
JID - 101181284
CON - AIDS. 2012 Mar 27;26(6):721-30. PMID: 22233655
EDAT- 2012/09/05 06:00
MHDA- 2012/09/05 06:01
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2012/09/05 06:01 [medline]
AID - 10.1586/eri.12.62 [doi]
PST - ppublish
SO  - Expert Rev Anti Infect Ther. 2012 Jul;10(7):737-41. doi: 10.1586/eri.12.62.