PMID- 22943556
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20121113
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 34
IP  - 10
DP  - 2012 Dec
TI  - Hyperbaric oxygen is effective in early stage of healing of experimental brain 
      abscess in rats.
PG  - 931-6
LID - 10.1179/1743132812Y.0000000091 [doi]
AB  - OBJECTIVES: Current therapy of brain abscess (BA) includes a combined approach 
      that involves antibiotics and minimal invasive surgery, but also hyperbaric 
      oxygen treatment (HBOT) as a supportive measure. Optimum treatment is still a 
      matter of significant controversy. METHODS: The experiment, previously approved 
      by a relevant ethical committee, involved 80 female Wistar rats. BA was 
      experimentally induced by inoculation of Staphylococcus aureus. The animals were 
      randomized into groups and treated either with antibiotics, HBOT, or with a 
      combination of both. RESULTS: Beneficial effect of HBOT was evident in groups 
      treated with HBOT or with a combination of antibiotic+HBOT. It was mainly 
      manifested on days three and five of the experiment and was evident as 
      statistically significant increase of a number of newly formed blood vessels, 
      increase in mean vascular density, and smaller abscess necrotic core. DISCUSSION: 
      Although the results of the present study should be interpreted cautiously, they 
      suggest that HBOT has an important but limited role in the treatment of BA.
FAU - Bilic, Ivica
AU  - Bilic I
AD  - Department of Neurology, University Hospital Center Split, Croatia. 
      ibilic@kbsplit.hr
FAU - Petri, Nadan M
AU  - Petri NM
FAU - Krstulja, Mira
AU  - Krstulja M
FAU - Vuckovic, Meri
AU  - Vuckovic M
FAU - Salamunic, Ilza
AU  - Salamunic I
FAU - Kraljevic, Katarina Sisko
AU  - Kraljevic KS
FAU - Capkun, Vesna
AU  - Capkun V
FAU - Lusic, Ivo
AU  - Lusic I
LA  - eng
PT  - Journal Article
DEP - 20120829
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
SB  - IM
MH  - Animals
MH  - Brain Abscess/microbiology/*therapy
MH  - *Disease Models, Animal
MH  - Female
MH  - Hyperbaric Oxygenation/*methods
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Staphylococcal Infections/metabolism/*therapy
MH  - *Staphylococcus aureus
MH  - Time Factors
MH  - Treatment Outcome
MH  - Wound Healing/*physiology
EDAT- 2012/09/05 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - ner2921 [pii]
AID - 10.1179/1743132812Y.0000000091 [doi]
PST - ppublish
SO  - Neurol Res. 2012 Dec;34(10):931-6. doi: 10.1179/1743132812Y.0000000091. Epub 2012 
      Aug 29.