PMID- 22943624
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20181202
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 29
IP  - 2
DP  - 2013 Feb
TI  - In vitro fertilization stimulation protocol for normal responder patients.
PG  - 109-12
LID - 10.3109/09513590.2012.712002 [doi]
AB  - The aim of this prospective observational study is to determine the different 
      outcomes of IVF/ICSI treatments after using antagonists or agonists of 
      gonadotrophin-releasing hormone (GnRH) for controlled ovarian hyperstimulation 
      (COH) in normal responder patients. Two hundred forty-seven patients undergoing 
      IVF treatment at the Centre of Reproductive Medicine, Rome (CERMER), from January 
      2005 to December 2008, were included in the study. Patients were stimulated 
      either with a standard long protocol with GnRH agonists (n = 156) or with GnRH 
      antagonists (n = 91). The use of GnRH antagonists resulted in a significant 
      reduction in the duration of the stimulation (Agonist Group 14.10 +/- 2.25 vs 
      Antagonist Group 11.34 +/- 2.11; p < 0.001) and in the amount of gonadotrophin (IU 
      of r-FSH) needed (Agonist Group 1878 +/- 1109 vs Antagonist Group 1331 +/- 1049; p = 
      0.0014). Moreover a lower number of cycles were cancelled with the antagonist 
      protocol (4.39 vs 6.41%). The GnRH antagonist protocol, when compared to the GnRH 
      agonist one, is associated with a similar clinical pregnancy rate, similar 
      implantation rate, significantly lower gonadotrophin requirement and shorter 
      duration of stimulation. For this reason, GnRH antagonists might be a good 
      treatment even for normal responder patients undergoing IVF.
FAU - Marci, R
AU  - Marci R
AD  - Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 
      Ferrara, Italy. roberto.marci@unife.it
FAU - Caserta, D
AU  - Caserta D
FAU - Lisi, F
AU  - Lisi F
FAU - Graziano, A
AU  - Graziano A
FAU - Soave, I
AU  - Soave I
FAU - Lo Monte, G
AU  - Lo Monte G
FAU - Patella, A
AU  - Patella A
FAU - Moscarini, M
AU  - Moscarini M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120903
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Fertility Agents, Female)
RN  - 0 (Follicle Stimulating Hormone, Human)
RN  - 0 (Hormone Antagonists)
RN  - 0 (Recombinant Proteins)
RN  - 0 (follitropin alfa)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 4TI98Z838E (Estradiol)
RN  - IX503L9WN0 (ganirelix)
SB  - IM
MH  - Adult
MH  - Embryo Implantation
MH  - Estradiol/blood/metabolism
MH  - Female
MH  - Fertility Agents, Female/administration & dosage/adverse effects/*pharmacology
MH  - Follicle Stimulating Hormone, Human/administration & dosage/adverse 
      effects/pharmacology
MH  - Gonadotropin-Releasing Hormone/administration & dosage/adverse 
      effects/agonists/analogs & derivatives/*antagonists & inhibitors/pharmacology
MH  - Hormone Antagonists/adverse effects/*pharmacology
MH  - Humans
MH  - Infertility, Female/*therapy
MH  - Oocyte Retrieval
MH  - Ovary/*drug effects/metabolism
MH  - Ovulation Induction/*methods
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Prospective Studies
MH  - Recombinant Proteins/administration & dosage/adverse effects/pharmacology
MH  - Rome/epidemiology
MH  - *Sperm Injections, Intracytoplasmic
MH  - Young Adult
EDAT- 2012/09/05 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.3109/09513590.2012.712002 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2013 Feb;29(2):109-12. doi: 10.3109/09513590.2012.712002. 
      Epub 2012 Sep 3.