PMID- 22943815
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20120904
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 48
IP  - 6
DP  - 2012 Jun
TI  - [Brain-derived neurotrophic factor and repair of retinal ganglion cells after 
      injury].
PG  - 567-71
AB  - Blocking of retrograde transport after the optic nerve injury results in 
      deprivation of neurotrophic support to retinal ganglion cells (RGCs), and leads 
      to apoptotic cell death in glaucoma. As an important member of neurotrophins, the 
      brain-derived neurotrophic factor (BDNF) plays a substantial role in the repair 
      of retinal ganglion cells injury, but its signaling pathway in the pathogenesis 
      of glaucoma remains unclear. This review focuses on the structure, distribution 
      and receptors of BDNF and its effects on RGC survival, axon regeneration and 
      relevant signaling pathway, to provide theoretical foundation for neuroprotective 
      treatment of glaucoma.
FAU - Han, Miao-miao
AU  - Han MM
AD  - Joint Shantou International Eye Center of Shantou University and Chinese 
      University of Hongkong, Shantou University Medical College, China.
FAU - Zhang, Ming-zhi
AU  - Zhang MZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - *Brain-Derived Neurotrophic Factor
MH  - Glaucoma
MH  - Humans
MH  - Neuroprotective Agents
MH  - Optic Nerve Injuries
MH  - *Retinal Ganglion Cells/metabolism/physiology
EDAT- 2012/09/05 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2012 Jun;48(6):567-71.